Duoseq — one test to find DNA and RNA changes in lymphoma
Validation of Duoseq as a Genomic Swiss Army Knife for the Diagnosis of Lymphomas
Testing whether a single combined DNA-and-RNA sequencing test (Duoseq) can quickly find the genetic changes doctors use to diagnose and guide treatment for people with lymphoma.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Data Driven Bioscience INC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11316167 on NIH RePORTER |
What this research studies
This project uses Duoseq, a lab method that sequences both DNA and RNA from the same biopsy sample and pairs it with software that reads results directly from the sequencer. The goal is to replace many separate, time-consuming lab tests by providing mutation, copy-number, translocation, and marker expression information in one workflow. The automated bioinformatics is designed to deliver these clinical readouts faster and with less manual interpretation by pathologists. The initial work focuses on validating the approach using lymphoma biopsy samples.
Who could benefit from this research
Good fit: People with suspected or confirmed lymphoma who are having a tumor biopsy or have available tumor tissue for sequencing would be the ideal candidates.
Not a fit: Patients without available tumor tissue or those whose care does not rely on molecular testing are unlikely to gain direct benefit from this work.
Why it matters
Potential benefit: If successful, Duoseq could shorten time to diagnosis, reduce the number of separate tests, and give clearer molecular information to guide lymphoma treatment decisions.
How similar studies have performed: DNA and RNA sequencing panels are already used in cancer diagnosis and have shown clinical value, but Duoseq’s novelty is combining both assays in one rapid workflow with integrated automated analysis.
Where this research is happening
Durham, United States
- Data Driven Bioscience INC — Durham, United States (Active)
Researchers
- Principal investigator: Happ, Lanie Elizabeth — Data Driven Bioscience INC
- Study coordinator: Happ, Lanie Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.