A new combination therapy to boost nerve growth and help recovery after chronic spinal cord injury
Official title: A Novel Combinatorial Therapy Targeting Neuroplasticity to Promote FunctionalRecovery in Chronic Spinal Cord Injury
Funded at Edward Hines Jr VA Hospital · NIH-11338243 · Data updated 2026-11-12
A treatment approach aims to help adults with long‑standing spinal cord injuries regain function by promoting nerve growth and repair in the spinal cord.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Edward Hines Jr VA Hospital NIH-funded |
| Lab location | 1 site (Hines, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| NIH project number | 1I01RD000457-01A2 |
| Project ID | NIH-11338243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with long-standing thoracic spinal cord contusion injuries, including Veterans and others receiving care at VA facilities.
✕Less likely to help
People without chronic contusive SCI or those with non-spinal injuries may not benefit from this approach.
What this research studies
This project focuses on people with chronic thoracic spinal cord injury and explores a therapy designed to encourage axons to grow and rejoin neural circuits. Researchers will consider how intrinsic nerve growth programs and the hostile scar environment interact, with the goal of improving motor abilities. The study will be conducted through the Edward Hines Jr VA Hospital and led by Dr. Martin Oudega, leveraging prior work on neuroplasticity and spinal cord repair. If successful, the approach could translate into strategies that help Veterans and others regain walking or arm/hand function after injury.
Why it matters
Potential benefit: If successful, the therapy could improve motor function and quality of life for people living with chronic SCI.
How similar studies have gone: Prior research in spinal cord repair has shown that promoting axon growth and overcoming inhibitory scar environments can improve outcomes in some models, but translating to chronic SCI in humans remains challenging.
Where this research is happening
-
Edward Hines Jr VA Hospital
Hines, United States Active
Researchers
- Principal investigator: Oudega, Martin — Edward Hines Jr VA Hospital
- Study coordinator: Oudega, Martin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.