NIH-funded research NIH-funded research

A new combination therapy to boost nerve growth and help recovery after chronic spinal cord injury

Official title: A Novel Combinatorial Therapy Targeting Neuroplasticity to Promote FunctionalRecovery in Chronic Spinal Cord Injury

Funded at Edward Hines Jr VA Hospital · NIH-11338243 · Data updated 2026-11-12

A treatment approach aims to help adults with long‑standing spinal cord injuries regain function by promoting nerve growth and repair in the spinal cord.

More Spinal Cord Injury research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionEdward Hines Jr VA Hospital
NIH-funded
Lab location1 site (Hines, United States)
Project startJune 1, 2026
Project endMay 31, 2031
Funding year2026
NIH project number1I01RD000457-01A2
Project IDNIH-11338243 on NIH RePORTER

Who could benefit from this research

Could help

Adults with long-standing thoracic spinal cord contusion injuries, including Veterans and others receiving care at VA facilities.

Less likely to help

People without chronic contusive SCI or those with non-spinal injuries may not benefit from this approach.

What this research studies

This project focuses on people with chronic thoracic spinal cord injury and explores a therapy designed to encourage axons to grow and rejoin neural circuits. Researchers will consider how intrinsic nerve growth programs and the hostile scar environment interact, with the goal of improving motor abilities. The study will be conducted through the Edward Hines Jr VA Hospital and led by Dr. Martin Oudega, leveraging prior work on neuroplasticity and spinal cord repair. If successful, the approach could translate into strategies that help Veterans and others regain walking or arm/hand function after injury.

Why it matters

Potential benefit: If successful, the therapy could improve motor function and quality of life for people living with chronic SCI.

How similar studies have gone: Prior research in spinal cord repair has shown that promoting axon growth and overcoming inhibitory scar environments can improve outcomes in some models, but translating to chronic SCI in humans remains challenging.

Where this research is happening

  • Edward Hines Jr VA Hospital
    Hines, United States
    Active

Researchers

  • Principal investigator: Oudega, Martin — Edward Hines Jr VA Hospital
  • Study coordinator: Oudega, Martin

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.