A database for analyzing gene sets related to diseases
Official title: The Molecular Signatures Database: A knowledgebase for gene set based analysis of genomic data
Funded at University of California, San Diego · NIH-11015639 · Data updated 2026-11-12
This study is working on a helpful online resource that collects information about genes from humans and mice, which can help scientists learn more about diseases and how they work, ultimately benefiting patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $666,637 |
| NIH project number | 1U24CA295532-01 |
| Project ID | NIH-11015639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include patients with genetic conditions or diseases that can be studied through genomic data analysis.
✕Less likely to help
Patients with conditions that are not influenced by genetic factors or do not have a genomic basis may not receive benefits from this research.
What this research studies
This research focuses on creating and maintaining the Molecular Signatures Database (MSigDB), an open-access resource that contains a vast collection of well-annotated gene sets from humans and mice. Patients can benefit from this research as it helps scientists understand the biological mechanisms behind diseases by using genomic data analysis methods. The database is continually updated through manual curation, computational analysis, and mining of public resources, making it a valuable tool for generating hypotheses for further studies. By providing insights into gene functions and biological processes, this research aims to enhance our understanding of various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for various diseases through enhanced genomic analysis.
How similar studies have gone: Previous research utilizing similar gene set analysis approaches has shown significant success in advancing our understanding of biological processes and disease mechanisms.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Mesirov, Jill P. — University of California, San Diego
- Study coordinator: Mesirov, Jill P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.