NRF2-ACSS2 Axis in Alcohol-Linked Esophageal Health
Official title: NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
Funded at Coriell Institute for Medical Research · NIH-11393724 · Data updated 2026-11-12
This grant studies how a cellular power switch (NRF2-ACSS2) drives alcohol-related changes in esophageal cells and tissue, with findings that could guide future prevention.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $574,358 |
| NIH project number | 5R01AA030026-06 |
| Project ID | NIH-11393724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults with a history of alcohol consumption or those at risk for alcohol-related esophageal changes who could contribute human cell samples or participate in future trials.
✕Less likely to help
People without alcohol exposure or esophageal risk factors may not directly benefit from this mechanistic study.
What this research studies
The research combines human cell experiments and mouse studies to understand how alcohol alters metabolism in esophageal tissue through the NRF2-ACSS2 pathway. It will look at how this axis affects metabolic reprogramming in human esophageal cells in the lab, then test and confirm these findings in mice, and finally test inhibitors to see if they can prevent harmful changes. The goal is to establish a mechanistic basis for preventing alcohol-related esophageal pathology by targeting NRF2 and ACSS2. If successful, this could pave the way for new preventive strategies in people who drink alcohol. The project is designed to lay a solid foundation for translating these insights into future therapies or interventions.
Why it matters
Potential benefit: If successful, the work could lead to new preventive strategies against alcohol-associated esophageal pathology.
How similar studies have gone: Previous work has shown NRF2-related pathways influence metabolic processes; this study extends that to alcohol-induced esophageal changes, with potential for translational impact.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Chen, Xiaoxin Luke — Coriell Institute for Medical Research
- Study coordinator: Chen, Xiaoxin Luke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.