Condition

Squamous Cell Carcinoma Head and Neck Cancer (HNSCC) clinical trials and research

• 6Clinical trials
• 4Countries

Newest Squamous Cell Carcinoma Head and Neck Cancer (HNSCC) clinical trials

All recruiting trials (6)

• Short-course (3-week) versus standard 6-week postoperative radiation for head and neck squamous cell carcinoma

  This will test whether a shorter, 3-week postoperative radiation schedule works as well as the standard 6-week schedule for adults (18–80) who had surgery for head and neck squamous cell carcinoma with certain intermediate risk features.

  Recruiting Phase 2/3 All India Institute of Medical Sciences · Jhajjar, Haryana · NCT07573956

• Nivolumab-IRDyE800CW imaging agent used before surgery in head and neck cancer

  This early-stage trial tests whether nivolumab labeled with IRDye800CW can safely be given before surgery to see if it helps image head and neck squamous cell carcinoma.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07460765

• Ivonescimab with or without ligufalimab versus pembrolizumab as first-line treatment for recurrent/metastatic PD-L1-positive head and neck squamous cell carcinoma

  This study tests whether ivonescimab alone or with ligufalimab works as a first-line treatment for PD-L1‑positive recurrent or metastatic head and neck cancer, compared with pembrolizumab.

  Recruiting Phase 3 Groupe Oncologie Radiotherapie Tete et Cou · Le Havre · NCT07264075

• ICG dye imaging to help find head and neck tumors during surgery

  We will try a fluorescent dye called ICG during surgery to see if it helps surgeons find tumor tissue in adults with mucosal head and neck squamous cell cancer who are at risk of recurrence.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07149207

• Immune response in neck lymph nodes of people with head and neck cancer.

  This project will test whether immune and genetic differences between the primary tumor and nearby neck lymph nodes, including sentinel nodes, indicate whether cancer has spread in people with HNSCC.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT07131566

• Testing blood samples for cancer DNA in head and neck cancer patients

  This study is testing if checking blood samples for cancer DNA can help predict if head and neck cancer patients will have a relapse after their treatment.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06606028

Related topics

Quick answers

How many Squamous Cell Carcinoma Head and Neck Cancer (HNSCC) clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (3 trials), France (1 trial), Sweden (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1, Phase 2/3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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