Condition

NSCLC Stage II clinical trials and research

• 5Clinical trials
• 3Countries

Newest NSCLC Stage II clinical trials

All recruiting trials (5)

• Adaptive Chemotherapy for PD-L1 High Resectable NSCLC: A Chemo-PHREE Trial

  This study tests cemiplimab in adults with resectable non-small cell lung cancer to see if surgery can be pursued without preceding chemotherapy for some patients.

  Recruiting Phase 2 University of Maryland, Baltimore · Indianapolis, Indiana and 4 other locations · NCT07746388

• Anti-CTLA-4 plus sintilimab and chemotherapy before surgery for resectable Stage II–III NSCLC

  This trial will test whether adding an anti-CTLA-4 antibody (IBI310) to sintilimab plus chemotherapy before surgery helps people with PD-L1–negative, resectable Stage II–III non-small cell lung cancer.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT07410975

• BIO 300 with thoracic radiation for early-stage non-small cell lung cancer and interstitial lung disease

  This trial will test whether adding BIO 300 to thoracic radiation lowers the chance of pneumonitis in people with stage I–II non-small cell lung cancer who also have interstitial lung disease.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07323732

• Pilot Precision Exercise Program for Lung Cancer Care

  This pilot will test whether a personalized, virtually supervised home exercise program delivered by telehealth can be implemented and helpful for people with stage II-III non-small cell lung cancer who are receiving chemotherapy or immunotherapy plus surgery.

  Recruiting at 2 sites University of Utah · Galveston, Texas and 1 other locations · NCT06945484

• Predicting response to immunotherapy and chemotherapy in lung cancer

  This study is testing if a special immune profile can help predict how well patients with lung cancer will respond to a combination of treatments before surgery.

  Recruiting Phase 2 University Hospital Heidelberg · Heidelberg, BaWü · NCT04865250

Related topics

Quick answers

How many NSCLC Stage II clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (3 trials), China (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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