Condition
Myeloproliferative Neoplasms (MPNs) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Myeloproliferative Neoplasms (MPNs) clinical trials that are recruiting, at sites in 5 countries (most in United States (3), Australia (2), France (1)). By phase: Phase 1 (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 5Countries
Newest Myeloproliferative Neoplasms (MPNs) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| DMR-001 in CALR-mutant myeloproliferative neoplasms | Phase 1 | Birmingham, Alabama and 35 other locations | Recruiting | Sep 30, 2026 |
| PRT12396 for people with high-risk polycythemia vera or myelofibrosis | Phase 1 | Los Angeles, California and 21 other locations | Recruiting | Mar 13, 2026 |
| MPN PROGRESSion Registry — tracking symptoms, treatments, and disease progression in people with MPNs. | — | Chicago, Illinois and 1 other locations | Recruiting | Jan 23, 2026 |
All recruiting trials (3)
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DMR-001 in CALR-mutant myeloproliferative neoplasms
This study tests DMR-001 alone for CALR-mutant essential thrombocythemia or myelofibrosis, and in combination with ruxolitinib for CALR-mutant myelofibrosis.
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PRT12396 for people with high-risk polycythemia vera or myelofibrosis
The team will try the oral drug PRT12396 in people with high-risk polycythemia vera or myelofibrosis to find safe doses and look for early signs of benefit.
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MPN PROGRESSion Registry — tracking symptoms, treatments, and disease progression in people with MPNs.
Track long-term symptoms, treatments, and disease progression in adults with myeloproliferative neoplasms to see how these conditions evolve over time.
Related topics
Quick answers
How many Myeloproliferative Neoplasms (MPNs) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 5 countries. The most sites are in United States (3 trials), Australia (2 trials), France (1 trial), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.