Condition

Myelofibrosis (MF) clinical trials and research

• 9Clinical trials
• 6Countries

Newest Myelofibrosis (MF) clinical trials

All recruiting trials (9)

• MPNdpoint: Long-term Look at Philadelphia-negative Myeloproliferative Neoplasms

  This study tests how outcomes differ for patients 16 and older with polycythemia vera, essential thrombocythemia, or myelofibrosis by collecting and analyzing clinical and treatment data.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan · NCT07863466

• Pacritinib Effectiveness in Real-world Settings

  This real-world study will see how pacritinib works for adults with myelofibrosis by looking back at medical records from several centers.

  Recruiting at 5 sites Swedish Orphan Biovitrum · New Haven, Connecticut and 4 other locations · NCT07774455

• PRT12396 for people with high-risk polycythemia vera or myelofibrosis

  The team will try the oral drug PRT12396 in people with high-risk polycythemia vera or myelofibrosis to find safe doses and look for early signs of benefit.

  Recruiting at 22 sites Phase 1 Prelude Therapeutics Incorporated · Los Angeles, California and 21 other locations · NCT07469891

• CCR2-based blood test and PET imaging to detect bone marrow fibrosis in myeloproliferative neoplasms

  This project tests whether a blood test measuring CCR2-positive cells and a CCR2-targeted PET scan can find and track bone marrow fibrosis in adults with myeloproliferative neoplasms.

  Recruiting Azienda Ospedaliero-Universitaria di Parma · Parma, Italy · NCT07419178

• MPN PROGRESSion Registry — tracking symptoms, treatments, and disease progression in people with MPNs.

  Track long-term symptoms, treatments, and disease progression in adults with myeloproliferative neoplasms to see how these conditions evolve over time.

  Recruiting at 2 sites MPN Research Foundation · Chicago, Illinois and 1 other locations · NCT07362225

• Early Tacrolimus Taper After Allogeneic Transplant

  This study tests whether stopping tacrolimus early after an allogeneic stem cell transplant is safe and feasible for people with AML, MDS, MF, CML, CMML, or GVHD risk after transplant.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT07302776

• Axatilimab plus ruxolitinib for people with myelofibrosis or CMML

  This trial tests whether adding axatilimab, an antibody that targets CSF1R, to ruxolitinib can help control disease and symptoms in adults with myelofibrosis or chronic myelomonocytic leukemia (CMML).

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT07128381

• Combining Roginolisib with Ruxolitinib for Myelofibrosis Patients Not Responding to JAK Inhibitors

  This study is testing if combining two medications, roginolisib and ruxolitinib, can help adults with myelofibrosis who haven't responded well to other treatments.

  Recruiting at 11 sites Phase 1/2 iOnctura · Florence, Florence and 11 other locations · NCT06887803

• Using low-dose Methotrexate for treating blood cancers

  This study is testing if adding low-dose Methotrexate to the treatment of blood cancers like Polycythemia Vera and Myelofibrosis can help reduce symptoms and improve spleen size for patients.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT06541249

Related topics

Quick answers

How many Myelofibrosis (MF) clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), Italy (4 trials), Spain (2 trials), United Kingdom (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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