Condition

Mild Autonomous Cortisol Secretion (MACS) clinical trials and research

• 7Clinical trials
• 1New in 30 days
• 3Countries

Newest Mild Autonomous Cortisol Secretion (MACS) clinical trials

All recruiting trials (7)

• Adrenal Diseases in Modena: A Patient Registry at Modena University Hospital

  This study collects medical histories and treatment data from patients with adrenal diseases to see how they are diagnosed and managed in Modena.

  Recruiting Azienda Ospedaliero-Universitaria di Modena · Modena, Modena · NCT07920198

• Tirzepatide after adrenalectomy for MACS

  This study tests whether adding tirzepatide after adrenalectomy helps control blood pressure and improve metabolic health in adults with mild autonomous cortisol secretion.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07573163

• Adrenalectomy versus semaglutide for metabolic health in mild autonomous cortisol secretion

  We are testing whether removing the adrenal gland or treating with semaglutide better improves insulin resistance and other metabolic measures in adults with mild autonomous cortisol secretion, and comparing semaglutide effects to matched adults without adrenal tumors.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07361874

• Metyrapone versus osilodrostat for metabolic autonomous cortisol secretion (MACS)

  This trial will test whether metyrapone or osilodrostat better lowers cortisol and improves health in adults with mild autonomous cortisol secretion (MACS) who are not having surgery.

  Recruiting Phase 4 Laikο General Hospital, Athens · Athens · NCT07268222

• Isturisa treatment for people with mild autonomous cortisol secretion (MACS)

  This trial will test whether Isturisa (osilodrostat) helps adults with MACS improve metabolic measures, blood pressure, weight, bone density, and quality of life.

  Recruiting Phase 4 Johns Hopkins University · Baltimore, Maryland · NCT07247058

• Metyrapone for Mild Autonomous Cortisol Secretion

  This study tests whether taking metyrapone by mouth for six months can safely reduce cortisol excess in adults with MACS compared with a placebo.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07138274

• Detecting cortisol secretion issues in patients with adrenal incidentalomas

  This study is trying to see how common mild cortisol secretion problems are in people with adrenal incidentalomas and which tests work best to find them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06344143

Related topics

Quick answers

How many Mild Autonomous Cortisol Secretion (MACS) clinical trials are recruiting right now?

7, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (5 trials), Italy (1 trial), Greece (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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