Condition
Autonomous Cortisol Secretion (ACS) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Autonomous Cortisol Secretion (ACS) clinical trials that are recruiting, in United States. By phase: Phase 2 (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest Autonomous Cortisol Secretion (ACS) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Adrenalectomy versus semaglutide for metabolic health in mild autonomous cortisol secretion | — | Dallas, Texas | Recruiting | Jan 23, 2026 |
| Metyrapone for Mild Autonomous Cortisol Secretion | Phase 2 | Rochester, Minnesota | Recruiting | Aug 22, 2025 |
| Low-dose (1 mg) osilodrostat for mild autonomous cortisol secretion | Phase 2 | Rochester, Minnesota | Recruiting | Aug 5, 2025 |
All recruiting trials (3)
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Adrenalectomy versus semaglutide for metabolic health in mild autonomous cortisol secretion
We are testing whether removing the adrenal gland or treating with semaglutide better improves insulin resistance and other metabolic measures in adults with mild autonomous cortisol secretion, and comparing semaglutide effects to matched adults without adrenal tumors.
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Metyrapone for Mild Autonomous Cortisol Secretion
This study tests whether taking metyrapone by mouth for six months can safely reduce cortisol excess in adults with MACS compared with a placebo.
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Low-dose (1 mg) osilodrostat for mild autonomous cortisol secretion
This trial will test whether taking 1 mg of osilodrostat daily is safe and can lower cortisol measures in adults with mild autonomous cortisol secretion.
Related topics
Quick answers
How many Autonomous Cortisol Secretion (ACS) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.