Condition

Major Depression Disorder clinical trials and research

• 7Clinical trials
• 6Countries

Newest Major Depression Disorder clinical trials

All recruiting trials (7)

• Near-infrared brain light for somatic symptoms in treatment-resistant depression

  This will test whether twice-weekly near‑infrared transcranial photobiomodulation at 10 Hz or 40 Hz can reduce depressive and physical (somatic) symptoms in people with treatment‑resistant depression who are already on antidepressants.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07543328

• Home transcranial direct current stimulation for major depression

  This study tests whether doing transcranial direct current stimulation (tDCS) at home—using either an accelerated or a conventional schedule—works as well and is as safe as receiving tDCS in a clinic for adults (18–65) with major depression who speak Spanish or Catalan.

  Recruiting at 2 sites Ionclinics & Deionic SL · L'Hospitalet de Llobregat, Barcelona and 2 other locations · NCT07510880

• Digital tools to help teens keep well when anxiety or depression are under control

  This study tests digital interventions to help 16–19 year-olds who’ve had anxiety or depression in the past keep feeling well for longer.

  Recruiting University of Oslo · Oslo · NCT07346911

• Brain stimulation to improve attention in major depression

  This will test whether brief bursts of magnetic brain stimulation (iTBS) can improve selective attention in adults with major depressive disorder.

  Recruiting University of Electronic Science and Technology of China · Chengdu, Sichuan · NCT07111169

• Blood markers that predict TMS response in treatment-resistant depression

  This project will test whether blood protein and metabolic markers can predict how well transcranial magnetic stimulation (TMS) works for people with treatment-resistant depression.

  Recruiting at 2 sites Gulhane Training and Research Hospital · Ankara, Ankara and 1 other locations · NCT07039370

• Long-term follow-up on treatments for major depression using Spravato or IV ketamine

  This study is looking at how well Spravato and IV ketamine work for treating major depression over five years, focusing on how patients feel about the treatments and their long-term safety.

  Recruiting at 6 sites Yale University · Milford, Connecticut and 7 other locations · NCT06725277

• Investigating the effects of DMT on depression

  This study is testing whether DMT can help people with depression feel better and how it affects their brain activity compared to healthy volunteers.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06671977

Related topics

Quick answers

How many Major Depression Disorder clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (2 trials), Norway (1 trial), Turkey (Türkiye) (1 trial), China (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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