Drug or treatment

Dostarlimab clinical trials

• 21Clinical trials
• 35Countries

Newest trials

All recruiting trials (21)

• Testing a B7‑H3 antibody–drug conjugate alone and with dostarlimab in recurrent/metastatic head and neck squamous cell carcinoma

  It tests an antibody–drug conjugate called GSK5764227 by itself or with the immunotherapy dostarlimab in adults with recurrent or metastatic head and neck squamous cell carcinoma who have received prior treatments.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07408063

• Dostarlimab with cisplatin, etoposide, and radiotherapy for small cell neuroendocrine cervical cancer

  This trial will test whether adding the immunotherapy drug dostarlimab to cisplatin/etoposide chemotherapy plus radiotherapy helps women with small cell neuroendocrine cervical carcinoma stay progression-free longer.

  Recruiting Phase 2 Chang Gung Memorial Hospital · Taoyuan, Taiwan · NCT07336147

• Neoadjuvant dostarlimab for locally advanced dMMR/MSI‑H rectal cancer in routine practice

  This project will try neoadjuvant dostarlimab in adults with dMMR/MSI‑H stage II–III rectal cancer to see how well it works and how safe it is in real-world clinical care.

  Recruiting National Cancer Institute, Naples · Naples and 1 other locations · NCT07269249

• Dostarlimab with carboplatin–paclitaxel for advanced or recurrent endometrial cancer in Chinese patients with dMMR/MSI-H

  This Phase 2 trial will test whether adding dostarlimab to carboplatin and paclitaxel helps Chinese patients with advanced or recurrent dMMR/MSI‑H endometrial cancer respond to treatment and tolerate the combination.

  Recruiting Phase 2 GlaxoSmithKline · Jinan, Shandong · NCT07108270

• Neoadjuvant dostarlimab before surgery for resectable stage III pMMR/MSS colon cancer

  This will test whether two pre-surgery infusions of the PD-1 drug dostarlimab help people with resectable stage III pMMR/MSS colon cancer.

  Recruiting Phase 2 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06830239

• Neoadjuvant immunotherapy and radiotherapy for advanced rectal cancer

  This study is testing if combining a new immunotherapy drug with short radiation treatment can help people with advanced rectal cancer avoid surgery and improve their chances of staying cancer-free.

  Recruiting Phase 3 Centre Hospitalier Universitaire Dijon · Dijon · NCT06762405

• Evaluating the effects of dostarlimab and vitamin D3 with mFOLFIRINOX in pancreatic cancer

  This study is testing a new combination of a cancer drug, vitamin D3, and chemotherapy to see if it can help people with untreated advanced pancreatic cancer.

  Recruiting Phase 2 Hopital Foch · Marseille and 4 other locations · NCT06757244

• Testing a new treatment for colon cancer using dostarlimab and chemotherapy

  This study is testing if combining a new drug called dostarlimab with chemotherapy can help people with certain types of colon cancer do better before surgery.

  Recruiting at 32 sites Phase 2 GlaxoSmithKline · Aalst and 32 other locations · NCT06567782

• Dostarlimab treatment for advanced or metastatic cancers with specific genetic markers

  This study is testing if the immunotherapy dostarlimab can help people with certain advanced cancers that have specific genetic markers feel better compared to standard chemotherapy.

  Recruiting Phase 2 Unicancer · Angers and 21 other locations · NCT06333314

• Evaluating dostarlimab as a non-surgical treatment for early-stage endometrial cancer

  This study is testing if a new immunotherapy drug called dostarlimab can be a safe and effective non-surgical treatment for women with early-stage endometrial cancer who want to keep their fertility or can't have surgery.

  Recruiting at 2 sites Phase 2 Queensland Centre for Gynaecological Cancer · Sydney, New South Wales and 2 other locations · NCT06278857

• Comparing Dostarlimab to Placebo after Chemoradiation for Head and Neck Cancer

  This study is testing if the immunotherapy drug Dostarlimab can help adults with advanced head and neck cancer feel better after they finish their chemoradiation treatment, compared to a placebo.

  Recruiting at 256 sites Phase 3 GlaxoSmithKline · Jonesboro, Arkansas and 276 other locations · NCT06256588

• Combining dostarlimab and LB-100 for treating ovarian clear cell carcinoma

  This study is testing whether combining two treatments, dostarlimab and LB-100, can help people with recurrent ovarian clear cell carcinoma live longer and feel better.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT06065462

• Using dostarlimab to avoid surgery in localized gastric cancer

  This study is testing if the drug dostarlimab can help patients with certain types of stomach cancer avoid surgery by seeing if their cancer completely responds to treatment.

  Recruiting at 17 sites Phase 2 GERCOR - Multidisciplinary Oncology Cooperative Group · Besançon and 17 other locations · NCT06059495

• Preventing second cancers with Dostarlimab treatment

  This study is testing if the drug Dostarlimab can help prevent second cancers in people who are at high risk after finishing treatment for their first cancer.

  Recruiting at 5 sites Phase 2 Centre Leon Berard · Caen and 4 other locations · NCT05855811

• Evaluating dostarlimab for resectable colon cancer

  This study is testing if adding a new immunotherapy called dostarlimab to standard chemotherapy can help people with certain types of resectable colon cancer do better.

  Recruiting at 229 sites Phase 3 GlaxoSmithKline · Tucson, Arizona and 265 other locations · NCT05855200

• Testing a new treatment approach for advanced endometrial cancer

  This study is testing a new treatment that combines radiation, chemotherapy, and immunotherapy to see if it helps people with advanced endometrial cancer live longer and feel better.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05819892

• Combining niraparib and dostarlimab for advanced cancers with brain metastases

  This study is testing if combining two drugs, niraparib and dostarlimab, can help people with advanced cancers that have spread to the brain feel better and respond to treatment.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05700721

• Combining Cabozantinib and Dostarlimab for Recurrent Gynecologic Carcinosarcoma

  This study is testing if combining two drugs, Cabozantinib and Dostarlimab, can help people with recurrent gynecologic carcinosarcoma who have already had chemotherapy.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05559879

• Combining dostarlimab and niraparib for advanced penile cancer

  This study is testing if a new combination of two drugs, dostarlimab and niraparib, can help people with advanced penile cancer who haven't had success with other treatments.

  Recruiting at 2 sites Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 1 other locations · NCT05526989

• Neoadjuvant treatment with dostarlimab for advanced colon cancer

  This study is testing if the immunotherapy drug dostarlimab can shrink tumors in patients with advanced colon cancer so they might not need surgery.

  Recruiting at 2 sites Phase 2 University of Iowa · Iowa City, Iowa and 1 other locations · NCT05239546

• Combining radiation with Dostarlimab for endometrial cancer treatment after surgery

  This study is testing if combining radiation therapy with the drug Dostarlimab can help women with a specific type of endometrial cancer feel better after surgery.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT04774419

Quick answers

How many clinical trials of Dostarlimab are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 35 countries. The most sites are in United States (9 trials), France (7 trials), Italy (5 trials), Belgium (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 14, Phase 3: 3, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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