Condition

HR+, HER2-, Advanced Breast Cancer clinical trials and research

• 5Clinical trials
• 4Countries

Newest HR+, HER2-, Advanced Breast Cancer clinical trials

All recruiting trials (5)

• Dalpiciclib with an aromatase inhibitor and olmesartan as first-line therapy for HR+/HER2- advanced breast cancer

  This trial tests whether adding dalpiciclib and olmesartan to an aromatase inhibitor helps people with HR+/HER2- advanced breast cancer respond to first-line treatment.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07810088

• AVZO-023 alone or with AVZO-021 and hormone therapy for advanced HR+/HER2- breast cancer

  This will test whether the oral drug AVZO-023, given alone or with AVZO-021 and hormone therapy, is safe and can help control advanced HR+/HER2- breast cancer.

  Recruiting at 16 sites Phase 1/2 Avenzo Therapeutics, Inc. · Los Angeles, California and 15 other locations · NCT06998407

• Combination treatment for advanced solid tumors using Invikafusp Alfa and Sacituzumab Govitecan

  This study is testing a new combination treatment of Invikafusp Alfa and Sacituzumab Govitecan to see if it helps people with advanced solid tumors, like certain types of breast cancer, feel better.

  Recruiting at 8 sites Phase 1/2 Marengo Therapeutics, Inc. · Los Angeles, California and 7 other locations · NCT06827613

• Treatment of advanced solid tumors with AVZO-021

  This study is testing a new oral medication called AVZO-021 to see if it can safely help people with advanced solid tumors, especially certain types of breast cancer and other cancers with specific genetic changes.

  Recruiting at 13 sites Phase 1/2 Avenzo Therapeutics, Inc. · New Haven, Connecticut and 12 other locations · NCT05867251

• Combining Ivermectin with Balstilimab for Advanced Triple Negative Breast Cancer

  This study is testing whether combining ivermectin with balstilimab or pembrolizumab can help people with advanced triple negative breast cancer by shrinking tumors and improving their quality of life.

  Recruiting Phase 1/2 Cedars-Sinai Medical Center · Los Angeles, California · NCT05318469

Related topics

Quick answers

How many HR+, HER2-, Advanced Breast Cancer clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (4 trials), Canada (1 trial), Australia (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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