Condition

Hormone Receptor Positive HER-2 Negative Breast Cancer clinical trials and research

• 9Clinical trials
• 17Countries

Newest Hormone Receptor Positive HER-2 Negative Breast Cancer clinical trials

All recruiting trials (9)

• Imaging Test for Metastatic Urothelial and Breast C cancers and NSCLC

  This imaging study tests how well the imaging agent works in people with metastatic urothelial cancer, various breast cancers, or NSCLC.

  Recruiting at 4 sites Early Phase 1 RayzeBio, Inc. · St Leonards, New South Wales and 5 other locations · NCT07671092

• Predicting outcomes for advanced breast cancer patients treated with CDK4/6 inhibitors and endocrine therapy

  This study is trying to see how well different CDK4/6 inhibitors combined with hormone therapy work for people with advanced breast cancer and how safe they are.

  Recruiting at 24 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Aviano and 23 other locations · NCT06805812

• Combining Alisertib with Endocrine Therapy for Advanced Breast Cancer

  This study is testing if adding a targeted therapy called alisertib to hormone treatment can help people with advanced breast cancer who haven’t responded to previous hormone therapies.

  Recruiting at 52 sites Phase 2 Puma Biotechnology, Inc. · Birmingham, Alabama and 52 other locations · NCT06369285

• Combining Elacestrant with Olaparib for Advanced Breast Cancer Treatment

  This study is testing if adding elacestrant to olaparib can help people with advanced breast cancer who have specific genetic mutations live longer without their cancer getting worse.

  Recruiting at 35 sites Phase 2 GBG Forschungs GmbH · Stuttgart, Baden-Wurttemberg and 35 other locations · NCT06201234

• BGB-43395 treatment for advanced breast cancer and other solid tumors

  This study is testing a new treatment called BGB-43395 for people with advanced breast cancer and other solid tumors to see if it works better alone or with other medications.

  Recruiting at 57 sites Phase 1 BeOne Medicines · Denver, Colorado and 60 other locations · NCT06120283

• Comparing two chemotherapy regimens for high-risk ER+/HER2- breast cancer

  This study is testing which chemotherapy treatment works better for people with early-stage high-risk breast cancer that is estrogen receptor positive and HER2 negative after surgery.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT05901428

• Investigating how menstrual cycle phases affect treatment decisions in HR+ HER2- breast cancer

  This study looks at how different phases of the menstrual cycle might affect treatment choices for women with hormone receptor-positive, HER2-negative breast cancer to help improve their care before surgery.

  Recruiting University Hospital Tuebingen · Tübingen · NCT05878314

• Combining VS-6766, Abemaciclib, and Fulvestrant for HR+/HER2-negative Breast Cancer

  This study is testing if a new drug called VS-6766, when combined with two other medications, can help people with hormone receptor-positive and HER2-negative metastatic breast cancer feel better.

  Recruiting at 2 sites Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT05608252

• Evaluating Vosilasarm for Advanced Breast Cancer Treatment

  This study is testing a new drug called Vosilasarm to see how well it works on its own and with other treatments for people with advanced breast cancer.

  Recruiting at 13 sites Phase 1/2 Ellipses Pharma · New Haven, Connecticut and 13 other locations · NCT05573126

Related topics

Quick answers

How many Hormone Receptor Positive HER-2 Negative Breast Cancer clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (4 trials), Germany (2 trials), Spain (2 trials), Australia (2 trials), New Zealand (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 2: 2, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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