Condition

Diabetic Macular Edema (DME) clinical trials and research

• 11Clinical trials
• 1New in 30 days
• 9Countries

Newest Diabetic Macular Edema (DME) clinical trials

All recruiting trials (11)

• Oral N-Acetylcysteine for Diabetic Macular Edema

  This study tests whether taking N-acetylcysteine by mouth can help people with center-involving diabetic macular edema who don’t yet need anti-VEGF therapy.

  Recruiting Phase 2 Tanta University · Damietta · NCT07917338

• 4D-150 gene therapy injected into the eye for adults with diabetic macular edema

  This study tests whether a one-time intravitreal injection of 4D-150 can help adults with diabetic macular edema compare to aflibercept.

  Recruiting at 23 sites Phase 3 4D Molecular Therapeutics · Scottsdale, Arizona and 93 other locations · NCT07867080

• Corticosteroid for Diabetic Macular Edema (DME) in Adults with Diabetic Retinopathy

  This trial tests whether intravitreal corticosteroid injections can influence inflammatory biomarkers and improve DME in adults with type 2 diabetes.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07843849

• Oral BGE-102 for center-involved diabetic macular edema (Phase 2)

  This trial tests whether taking BGE-102 by mouth, alone or with an anti-VEGF drug, can help preserve or improve vision in adults with center-involved diabetic macular edema.

  Recruiting at 16 sites Phase 2 BioAge Labs, Inc. · Bakersfield, California and 15 other locations · NCT07812090

• Tabirafusp Tedromer vs Aflibercept for Diabetic Macular Edema (DME)

  This study tests whether Tabirafusp Tedromer can work as well as or better than Aflibercept to help people with Diabetic Macular Edema.

  Recruiting at 52 sites Phase 3 Kodiak Sciences Inc · Scottsdale, Arizona and 51 other locations · NCT07734844

• Early imaging changes with faricimab versus biosimilar ranibizumab for diabetic retinal disease

  This trial will see if faricimab or a biosimilar ranibizumab causes different early OCT and OCTA imaging changes in adults with diabetic retinopathy or diabetic macular edema who need anti-VEGF injections.

  Recruiting Osijek University Hospital · Osijek · NCT07520045

• Comparing BAT5906 and Lucentis for diabetic macular edema

  This test will see if BAT5906 works as well as Lucentis to improve vision in adults with diabetic macular edema.

  Recruiting at 47 sites Phase 3 Bio-Thera Solutions · Beijing, Beijing Municipality and 49 other locations · NCT07515079

• LX111 gene therapy for adults with diabetic macular edema.

  This treatment will try a single eye injection of LX111 gene therapy in adults with diabetic macular edema to see if it is safe and reduces retinal swelling and improves vision.

  Recruiting Early Phase 1 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai and 1 other locations · NCT07362927

• Effects of Faricimab on kidney function in diabetic patients

  This study is testing if a new eye injection called Faricimab can help improve kidney function in people with diabetes compared to a standard treatment.

  Recruiting University Hospital, Alexandroupolis · Alexandroupoli, Evros and 1 other locations · NCT06929507

• Investigating metabolic and lipid profiles in diabetic eye disease

  This study is trying to see how blood and urine samples from people with diabetes relate to eye damage caused by diabetic eye disease and if gut bacteria play a role in this.

  Recruiting Hywel Dda Health Board · Llanelli, Wales · NCT06914778

• High-dose aflibercept for diabetic macular edema after vitrectomy

  We will try a higher dose of aflibercept (8 mg) to see if it better controls diabetic macular edema in people who have had vitrectomy.

  Recruiting Phase 4 Retina Consultants of Orange County · Fullerton, California · NCT06662994

Related topics

Quick answers

How many Diabetic Macular Edema (DME) clinical trials are recruiting right now?

11, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (5 trials), China (3 trials), Japan (1 trial), Puerto Rico (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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