Condition
CLOVES Syndrome clinical trials and research
As of November 12, 2026, Find a Trial lists 3 CLOVES Syndrome clinical trials that are recruiting, at sites in 11 countries (most in United States (3), South Korea (1), Taiwan (1)). By phase: Phase 3 (1), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 11Countries
Newest CLOVES Syndrome clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| KP-001 vs placebo for vascular and lymphatic malformations in children and adults | Phase 3 | Charleston, South Carolina and 4 other locations | Recruiting | Dec 16, 2025 |
| Treatment for PIK3CA-related overgrowth and malformations using RLY-2608 | Phase 2 | Phoenix, Arizona and 39 other locations | Recruiting | Jan 23, 2025 |
| Registry for patients with lymphatic anomalies | — | Boston, Massachusetts | Recruiting | Mar 26, 2015 |
All recruiting trials (3)
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KP-001 vs placebo for vascular and lymphatic malformations in children and adults
This trial tests whether KP-001 helps reduce symptoms in people aged 2 and older with common venous or lymphatic malformations or KTS/CLOVES, compared with a placebo.
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Treatment for PIK3CA-related overgrowth and malformations using RLY-2608
This study is testing a new treatment called RLY-2608 to see if it can help adults and children with PIK3CA-related overgrowth and malformations feel better.
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Registry for patients with lymphatic anomalies
This study is collecting information from people with lymphatic anomalies to see how these conditions affect their health and treatment over time.
Related topics
Quick answers
How many CLOVES Syndrome clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 11 countries. The most sites are in United States (3 trials), South Korea (1 trial), Taiwan (1 trial), Australia (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.