Condition
PIK3CA-Related Overgrowth Spectrum (PROS) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 PIK3CA-Related Overgrowth Spectrum (PROS) clinical trials that are recruiting, at sites in 14 countries (most in Australia (2), Belgium (2), France (2)). By phase: Phase 2 (2), Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 14Countries
Newest PIK3CA-Related Overgrowth Spectrum (PROS) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Alpelisib for children and adults with PIK3CA-related overgrowth spectrum (PROS) | Phase 2 | Sacramento, California and 40 other locations | Recruiting | May 30, 2025 |
| Evaluating CYH33 for PIK3CA-related overgrowth and vascular malformations | Phase 1/2 | Beijing, Beijing Municipality and 14 other locations | Recruiting | May 16, 2025 |
| Treatment for PIK3CA-related overgrowth and malformations using RLY-2608 | Phase 2 | Phoenix, Arizona and 39 other locations | Recruiting | Jan 23, 2025 |
All recruiting trials (3)
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Alpelisib for children and adults with PIK3CA-related overgrowth spectrum (PROS)
This project will try daily oral alpelisib to see if it reduces overgrowth and improves symptoms in children and adults with PROS.
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Evaluating CYH33 for PIK3CA-related overgrowth and vascular malformations
This study is testing a new treatment called CYH33 to see if it can help people with PIK3CA-related overgrowth and vascular problems feel better and have fewer side effects.
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Treatment for PIK3CA-related overgrowth and malformations using RLY-2608
This study is testing a new treatment called RLY-2608 to see if it can help adults and children with PIK3CA-related overgrowth and malformations feel better.
Related topics
Quick answers
How many PIK3CA-Related Overgrowth Spectrum (PROS) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 14 countries. The most sites are in Australia (2 trials), Belgium (2 trials), France (2 trials), Germany (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.