Condition

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative clinical trials and research

• 4Clinical trials
• 3Countries

Newest B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative clinical trials

All recruiting trials (4)

• Full-course immunotherapy plus chemotherapy for newly diagnosed Ph-negative B-cell ALL

  This phase 2 test gives blinatumomab throughout treatment with reduced-dose chemotherapy, and uses CAR-T cells and transplant as needed, to try to improve two-year relapse-free survival in adults with newly diagnosed Ph-negative B-cell ALL.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07564453

• Erwinia asparaginase with chemotherapy for high‑risk adults with newly diagnosed Philadelphia‑negative acute lymphoblastic leukemia or lymphoblastic lymphoma

  This trial tries Erwinia-derived asparaginase together with induction and consolidation chemotherapy in adults 18–54 with newly diagnosed high‑risk, Philadelphia chromosome–negative ALL or lymphoblastic lymphoma.

  Recruiting at 4 sites Phase 2 City of Hope Medical Center · Phoenix, Arizona and 7 other locations · NCT06918431

• Inotuzumab ozogamicin and blinatumomab with optional ponatinib for CD22-positive B-cell acute lymphoblastic leukemia

  This trial will test whether inotuzumab ozogamicin followed by blinatumomab, with or without ponatinib, can help people with CD22-positive B-cell acute lymphoblastic leukemia who are newly diagnosed, have relapsed, or are refractory to prior therapy.

  Recruiting at 89 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 284 other locations · NCT03739814

• Using inotuzumab ozogamicin with chemotherapy to treat acute lymphoblastic leukemia

  This study is testing if a new drug combined with lighter chemotherapy can help older patients with acute lymphoblastic leukemia who can't handle stronger treatments.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT01371630

Related topics

Quick answers

How many B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative clinical trials are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (3 trials), China (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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