Drug or treatment

Ponatinib clinical trials

• 10Clinical trials
• 10Countries

Newest trials

All recruiting trials (10)

• LP-118 in combination with standard therapy for newly diagnosed Ph+ ALL

  This study tests whether adding LP-118 to the standard therapy for adults with Philadelphia chromosome–positive ALL is safe and useful.

  Recruiting at 2 sites Phase 1 Wake Forest University Health Sciences · Charlotte, North Carolina and 1 other locations · NCT07614022

• Dose‑adjusted EPOCH chemotherapy with or without rituximab plus ponatinib for newly diagnosed Philadelphia chromosome–positive B‑cell ALL/lymphoblastic lymphoma

  This treatment plan tests whether adding the BCR‑ABL inhibitor ponatinib to dose‑adjusted EPOCH chemotherapy, with rituximab for CD20‑positive disease, helps adults newly diagnosed with Philadelphia chromosome–positive B‑cell acute lymphoblastic leukemia or lymphoblastic lymphoma.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07224100

• Using asciminib to treat chronic myeloid leukemia patients with a specific mutation

  This study is testing if a new drug called asciminib can help people with chronic myeloid leukemia who have a specific mutation and haven't had success with other treatments.

  Recruiting at 6 sites Phase 2 Novartis · Bordeaux and 5 other locations · NCT06514534

• Investigating a new drug combination for relapsed acute lymphoblastic leukemia

  This study is testing a new combination of drugs to see if it can safely help patients with relapsed acute lymphoblastic leukemia feel better and improve their treatment outcomes.

  Recruiting at 2 sites Phase 1/2 University of Chicago · Chicago, Illinois and 1 other locations · NCT06207123

• Evaluating ponatinib treatment in chronic myeloid leukemia patients

  This study is testing how well the drug ponatinib works and how safe it is for people with chronic myeloid leukemia who are on their second, third, or fourth round of treatment.

  Recruiting at 5 sites University of Pisa · Cagliari and 4 other locations · NCT06119269

• Comparing treatments for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

  This study tests whether Ponatinib or Imatinib, both with low-dose chemotherapy, can help adults with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia feel better, and looks at how Blinatumomab can be used for those who respond well or not to these treatments.

  Recruiting at 81 sites Phase 2 Goethe University · Aachen and 84 other locations · NCT06061094

• Using ponatinib to treat children with advanced leukemias, lymphomas, or solid tumors

  This study is testing if ponatinib can help children with hard-to-treat leukemias, lymphomas, or solid tumors feel better and have more treatment options.

  Recruiting at 22 sites Phase 1/2 Incyte Corporation · Ghent and 22 other locations · NCT03934372

• Inotuzumab ozogamicin and blinatumomab with optional ponatinib for CD22-positive B-cell acute lymphoblastic leukemia

  This trial will test whether inotuzumab ozogamicin followed by blinatumomab, with or without ponatinib, can help people with CD22-positive B-cell acute lymphoblastic leukemia who are newly diagnosed, have relapsed, or are refractory to prior therapy.

  Recruiting at 89 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 284 other locations · NCT03739814

• Combining blinatumomab, methotrexate, cytarabine, and ponatinib for treating certain types of leukemia

  This study is testing a new combination of four medications to see if it can help people with certain types of leukemia that have come back or didn't respond to previous treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT03263572

• Using ponatinib for patients with chronic myeloid leukemia who didn't respond to other treatments

  This study is testing if ponatinib can help people with chronic myeloid leukemia who didn't respond to other treatments feel better and improve their health.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT01746836

Quick answers

How many clinical trials of Ponatinib are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), France (2 trials), Italy (2 trials), Puerto Rico (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →