Condition

Autosomal Dominant Polycystic Kidney Disease (ADPKD) clinical trials and research

• 6Clinical trials
• 7Countries

Newest Autosomal Dominant Polycystic Kidney Disease (ADPKD) clinical trials

All recruiting trials (6)

• VX-407 pharmacokinetics after a single dose in adults with ADPKD

  This study tests how VX-407 is absorbed, distributed, metabolized, and excreted after a one-time oral dose in adults with polycystic kidney disease.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Lincoln, Nebraska · NCT07868926

• How VX-407 interacts with common birth control pills

  This study tests whether VX-407 affects how birth control pills work in people with ADPKD.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Montreal · NCT07792408

• Renal embolization with EVOH for adults on dialysis with ADPKD

  This study tests whether blocking blood flow to very large polycystic kidneys with the liquid embolic EVOH can shrink kidney size and reduce symptoms in adults on dialysis with ADPKD.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Lombardy · NCT07535385

• Ren-Nu: a kidney-focused ketogenic diet program for people with polycystic kidney disease

  This 16-week pilot will try a dietitian-led, kidney-safe ketogenic program plus KetoCitra in adults with ADPKD to improve metabolic health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07454174

• High blood pressure in children and teenagers at risk of ADPKD

  This project will use MRI, blood tests, arterial stiffness measures, and ambulatory blood pressure monitoring to see how common high blood pressure is in 12–17-year-olds who have a parent with ADPKD.

  Recruiting King's College London · London · NCT07260071

• Evaluating the safety of PYC-003 for treating a kidney disease

  This study is testing a new drug called PYC-003 to see if it's safe for people with a specific type of kidney disease and healthy adults.

  Recruiting at 12 sites Phase 1 PYC Therapeutics · Southport, Gold Coast and 11 other locations · NCT06714006

Quick answers

How many Autosomal Dominant Polycystic Kidney Disease (ADPKD) clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (2 trials), Italy (1 trial), United Kingdom (1 trial), Canada (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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