High blood pressure in children and teenagers at risk of ADPKD
Family Study of Early Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
This project will use MRI, blood tests, arterial stiffness measures, and ambulatory blood pressure monitoring to see how common high blood pressure is in 12–17-year-olds who have a parent with ADPKD.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 12 Years to 17 Years |
| Sex | All |
| Sponsor | King's College London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT07260071 on ClinicalTrials.gov |
What this trial studies
This observational project recruits adolescents aged 12–17 with a parent who has clinically confirmed autosomal dominant polycystic kidney disease and combines MRI imaging with genetic testing to identify ADPKD. Participants undergo office and ambulatory blood pressure measurement, non-invasive arterial stiffness testing, cardiac and renal MRI, and a blood sample for genetics and biomarkers. The aim is to estimate the true prevalence of hypertension in a general population sample of at-risk young people rather than cases seen in specialist centers. Results will inform whether earlier screening and treatment of blood pressure in this group should be recommended.
Who should consider this trial
Good fit: Ideal candidates are 12–17-year-olds who can tolerate MRI and blood tests, have a parent with confirmed ADPKD, and (with parental consent where required) agree to genetic testing.
Not a fit: Patients aged 18 or older, those unwilling to undergo genetic testing or MRI, or those with comorbid conditions that confound results are unlikely to benefit from participating.
Why it matters
Potential benefit: If successful, the project could uncover undiagnosed high blood pressure in at-risk adolescents and support earlier treatment to reduce long-term cardiovascular and kidney risk.
How similar studies have performed: Previous reports from specialist pediatric nephrology clinics have found hypertension in up to about 25% of adolescents with ADPKD, but population-based screening using MRI plus genetic confirmation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 12 - 17 years at the time of consent * Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test) * Parent with confirmed clinical diagnosis of ADPKD * Parent (if child \<16 years) or both parent and young person (if \>=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this. Exclusion Criteria: * 18 years or above at the time of study entry * Unable to tolerate key study investigations * Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations * Unwilling to undergo genetic testing for ADPKD
Where this trial is running
London
- Evelina London Children's Hospital — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Manish Sinha, PhD, MRCP (UK), MRCPCH — King's College London
- Study coordinator: Benjamin Boxer, PhD
- Email: gstt.hiya.pkd@nhs.net
- Phone: +44 20 7188 4770
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.