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Advanced/Metastatic Solid Tumors clinical trials and research

• 11Clinical trials
• 12Countries

Newest Advanced/Metastatic Solid Tumors clinical trials

All recruiting trials (11)

• HLX316 first-in-human dose study in advanced/metastatic solid tumors

  A first-in-human, Phase 1 study tests HLX316 to see if it is safe and tolerable and to get early signs of how it behaves in the body and whether it shows any tumor-killing activity in adults with advanced solid tumors.

  Recruiting Phase 1 Shanghai Henlius Biotech · Chongqing and 4 other locations · NCT07541534

• HLX48 first-in-human safety study in advanced solid tumors

  This early-phase study tests HLX48 in adults with advanced/metastatic solid tumors to see if it is safe and how it behaves in the body.

  Recruiting at 2 sites Phase 1 Shanghai Henlius Biotech · North Ryde, New South Wales and 6 other locations · NCT07473726

• SYS6043 treatment for advanced or metastatic solid tumors

  We will test SYS6043, a B7‑H3‑targeted antibody‑drug conjugate, in adults with advanced or metastatic solid tumors who have progressed on or are intolerant of standard therapies.

  Recruiting Phase 1/2 CSPC Megalith Biopharmaceutical Co.,Ltd. · Beijing, Beijing Municipality · NCT07415863

• HLX37 treatment for advanced or metastatic solid tumors, including non-small cell lung cancer

  This trial tests HLX37, given alone or with chemotherapy, to see if it is safe and how the body handles it in adults with advanced or metastatic solid tumors including non-small cell lung cancer.

  Recruiting at 2 sites Early Phase 1 Shanghai Henlius Biotech · Shanghai and 1 other locations · NCT07274813

• DB-1317 for selected advanced or metastatic solid tumors

  This study will try DB-1317, given every three weeks, in adults with advanced or metastatic solid tumors that have progressed after standard treatments.

  Recruiting at 14 sites Phase 1 DualityBio Inc. · Los Angeles, California and 13 other locations · NCT07141706

• MHB088C treatment for adults with advanced solid tumors

  This study will test MHB088C to see if it is safe and shows early signs of benefit in adults with advanced or metastatic solid tumors.

  Recruiting Phase 1/2 Qilu Pharmaceutical Co., Ltd. · Beijing · NCT07102004

• PF-08046876 for people with advanced solid tumors

  This trial tests a new antibody–drug conjugate called PF-08046876 given by IV in adults with advanced bladder, lung, head and neck, esophageal, or pancreatic cancers to see if it is safe and how it affects tumors.

  Recruiting at 30 sites Phase 1 Pfizer · Duarte, California and 30 other locations · NCT07090499

• Testing HRS-6719 in patients with advanced solid tumors

  This study is testing a new treatment called HRS-6719 to see if it can help people with advanced solid tumors that have a specific genetic deficiency feel better and improve their health.

  Recruiting at 2 sites Phase 1/2 Shandong Suncadia Medicine Co., Ltd. · Harbin, Heilongjiang and 1 other locations · NCT06922357

• Testing ATG-022 for advanced solid tumors

  This study is testing a new treatment called ATG-022 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 21 sites Phase 1 Antengene Corporation · Adelaide and 21 other locations · NCT05718895

• Combining ADG126 with Pembrolizumab for Advanced Solid Tumors

  This study is testing a new combination of two cancer treatments, ADG126 and Pembrolizumab, to see if they can help people with advanced solid tumors who have run out of other treatment options.

  Recruiting at 16 sites Phase 1/2 Adagene Inc · Scottsdale, Arizona and 20 other locations · NCT05405595

• Testing a new bispecific antibody for advanced solid tumors

  This study is testing a new treatment called MCLA-158 to see if it can help people with advanced solid tumors, especially those with metastatic colorectal cancer, when other options have run out.

  Recruiting at 45 sites Phase 1/2 Genmab · La Jolla, California and 53 other locations · NCT03526835

Related topics

Quick answers

How many Advanced/Metastatic Solid Tumors clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in China (10 trials), United States (4 trials), Australia (3 trials), Spain (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 1/2: 5, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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