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Advanced Malignant Solid Tumor clinical trials and research

• 18Clinical trials
• 5Countries

Newest Advanced Malignant Solid Tumor clinical trials

All recruiting trials (18)

• Three-dimensional lattice radiotherapy with PD-1/PD-L1 inhibitors for advanced solid tumors

  This study tests whether adding lattice radiotherapy to PD-1/PD-L1 inhibitors is safe and helps people with advanced solid tumors that have grown or spread.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Shenzhen, Guangdong · NCT07865793

• YH02 injection for intratumor therapy in advanced solid tumors

  This phase 2 study tests YH02 injected directly into tumors to see if it can help people with advanced solid cancers who have no effective standard treatments left.

  Recruiting Phase 2 Tianjin First Central Hospital · Tianjin · NCT07697937

• VG2025: a targeted therapy for advanced solid tumors

  This trial tests VG2025, an oncolytic HSV-1 therapy, in adults with advanced solid tumors that have stopped responding to standard treatments to see if it is safe and tolerable and to find a potential starting dose for future studies.

  Recruiting Phase 1/2 Virogin Biotech Ltd. · Shanghai · NCT07682870

• Immunotherapy with NY-ESO-1 TCR dnTGFβRII cells for ovarian cancer and other advanced solid tumors

  This trial tests a gene-modified T cell therapy, given with or without decitabine, in adults whose tumors express NY-ESO-1.

  Recruiting Phase 1/2 University of Chicago · Chicago, Illinois · NCT07389239

• First-in-human use of PLT012 in adults with advanced solid tumors

  This study will try different doses of an experimental drug called PLT012 given by IV every three weeks in adults with advanced solid tumors to find safe doses and see if it shrinks tumors.

  Recruiting at 4 sites Phase 1 Pilatus Biosciences Inc · Los Angeles, California and 3 other locations · NCT07337525

• MHB009C for adults with advanced solid tumors

  This trial will try MHB009C, an experimental injectable drug, in adults with advanced solid tumors who have no standard treatment options.

  Recruiting Phase 1/2 Minghui Pharmaceutical (Hangzhou) Ltd · Shanghai, Shanghai Municipality · NCT07326488

• Early-phase test of RPTR-1-201 for advanced solid tumors

  This trial will try RPTR-1-201 alone and with an anti‑PD‑1 antibody to see if it is safe and helps adults with advanced solid tumors.

  Recruiting at 12 sites Phase 1/2 Repertoire Immune Medicines · Grand Rapids, Michigan and 11 other locations · NCT07293754

• VG2062, an oncolytic HSV-1 therapy for people with advanced solid tumors.

  This trial will try VG2062, a genetically engineered herpes virus designed to stimulate anti-tumor immunity, in adults with advanced solid tumors that no longer respond to standard treatments.

  Recruiting Phase 1 Virogin Biotech Ltd. · Hebei · NCT07262164

• MHB048C treatment for advanced solid tumors, including metastatic castration‑resistant prostate cancer

  This study will test whether the experimental drug MHB048C is safe and shows signs of benefit in adults with advanced solid tumors, including metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1/2 Minghui Pharmaceutical (Hangzhou) Ltd · Shanghai, Shanghai Municipality · NCT07192120

• MHB042C for people with advanced solid tumors

  This study will try MHB042C injections in adults whose advanced solid tumors have stopped responding to standard treatments.

  Recruiting Phase 1/2 Minghui Pharmaceutical (Hangzhou) Ltd · Guangzhou, Guangdong · NCT07192107

• MHB036C combined with MHB039A for advanced breast cancer and other advanced solid tumors

  This trial will test whether the injectable combination of MHB036C and MHB039A is safe, well tolerated, and can shrink or control tumors in adults with advanced breast cancer or other advanced solid tumors.

  Recruiting Phase 2 Minghui Pharmaceutical (Hangzhou) Ltd · Shanghai, Shanghai Municipality · NCT07130383

• Combination of MHB088C and MHB039A for advanced solid tumors

  This will test whether combining two experimental drugs, MHB088C and MHB039A, is safe and can help adults with advanced solid tumors that haven't responded to standard treatments.

  Recruiting Phase 1/2 Minghui Pharmaceutical (Hangzhou) Ltd · Shanghai, Shanghai Municipality · NCT07126665

• SCTB39-1 for adults with advanced solid tumors (Phase 1/2 dose-escalation and expansion)

  This trial will try SCTB39-1 in adults with advanced malignant solid tumors to see if it is safe and can shrink or slow tumors.

  Recruiting Phase 1/2 Sinocelltech Ltd. · Beijing · NCT07050641

• MHB118C injection for advanced solid tumors

  This trial tests whether MHB118C injection is safe and shows signs of benefit in adults with advanced solid tumors who have exhausted standard treatment options.

  Recruiting Phase 1 Minghui Pharmaceutical (Hangzhou) Ltd · Shanghai · NCT07045454

• MT027 treatment for patients with pleural malignant tumors

  This study is testing a new treatment called MT027 for patients with pleural malignant tumors to see if it's safe and how well it works after they have already received standard treatment.

  Recruiting Phase 1 Suzhou Maximum Bio-tech Co., Ltd. · Beijing · NCT06726564

• Treatment of advanced solid tumors with IDOV-SAFE

  This study is testing a new treatment called IDOV-SAFE to see if it can help people with advanced solid tumors who haven't had success with other therapies.

  Recruiting Early Phase 1 Fudan University · Shanghai · NCT06718946

• Evaluating JSKN016 in patients with advanced malignant solid tumors

  This study is testing a new drug called JSKN016 to see if it is safe and what the right dose is for people with advanced solid tumors that have spread.

  Recruiting at 2 sites Phase 1 Jiangsu Alphamab Biopharmaceuticals Co., Ltd · Fuzhou, Fujian and 1 other locations · NCT06592417

• Evaluating VG2025 for patients with advanced solid tumors

  This study is testing a new injection called VG2025 to see if it can be safely used to help people with advanced solid tumors that haven't responded to other treatments.

  Recruiting Phase 1 Virogin Biotech Ltd. · Hangzhou, Zhejiang · NCT05477849

Related topics

Quick answers

How many Advanced Malignant Solid Tumor clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (15 trials), United States (3 trials), Ireland (1 trial), Portugal (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 8, Phase 1: 6, Phase 2: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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