PHASE2; PHASE3 ·
Biohaven Pharmaceuticals, Inc. ·
NCT06309966
This study is testing a new drug called BHV-7000 to see if it can help adults with hard-to-treat focal epilepsy who haven't found relief from other treatments.
Why this is a good match: Adult trial of a new anti-seizure drug (BHV-7000) for hard-to-treat focal epilepsy — directly therapeutic for drug-resistant focal epilepsy in adults.
Conditions:
Focal Epilepsy, Epilepsy, Seizure, Refractory Epilepsy, Partial Epilepsy
PHASE2; PHASE3 ·
Biohaven Pharmaceuticals, Inc. ·
NCT06132893
This study is testing a new treatment called BHV-7000 to see if it can help adults with difficult-to-treat focal onset epilepsy reduce their seizures.
Why this is a good match: Another BHV-7000 trial for difficult-to-treat focal-onset epilepsy in adults — direct treatment option.
Conditions:
Focal Epilepsy, Epilepsy, Seizure, Refractory Epilepsy, Partial Epilepsy
PHASE2 ·
Rapport Therapeutics Inc. ·
NCT07219407
This trial will try RAP-219, an investigational anti-seizure medication, in adults with refractory focal seizures to see if it is safe long-term and helps reduce seizures.
Why this is a good match: Long-term study of RAP-219 in adults with refractory focal seizures — relevant if patient has focal refractory epilepsy.
Conditions:
Focal Epilepsy, Epilepsy, Refractory Focal Epilepsy, Seizure, Focal Seizure
PHASE2 ·
Rapport Therapeutics Inc. ·
NCT06377930
This study is testing a new drug called RAP-219 to see if it can help adults with hard-to-treat focal epilepsy who have a special device implanted to manage their seizures.
Why this is a good match: RAP-219 study for adults with focal epilepsy who have a seizure-management device — therapeutic but limited to device recipients.
Conditions:
Focal Onset Seizures, Epilepsy, RNS, long episode, FOS
PHASE2; PHASE3 ·
Biohaven Pharmaceuticals, Inc. ·
NCT06425159
This study is testing if a new treatment called BHV-7000 can help adults with generalized epilepsy and tonic-clonic seizures have better control over their seizures.
Why this is a good match: BHV-7000 trial for adults with generalized seizures (tonic-clonic) — relevant for generalized epilepsy patients.
Conditions:
Generalized Epilepsy, Idiopathic Generalized Epilepsy, Generalized, Epilepsy, tonic-clonic
EARLY_PHASE1 ·
Xuanwu Hospital, Beijing ·
NCT06719791
This study is testing if sirolimus can help people with drug-resistant epilepsy by reducing the number of seizures they have.
Why this is a good match: Sirolimus tested for drug‑resistant epilepsy — potential benefit for refractory cases, particularly if mTOR pathway involved.
Conditions:
Epilepsy, Drug Resistant, Sirolomus, Focal Refractory Epilepsy, mTOR pathway
EARLY_PHASE1 ·
Xuanwu Hospital, Beijing ·
NCT07095933
This trial will test whether giving the mTOR inhibitor everolimus shortly after seizures can help reduce further seizures and abnormal brain activity in adults with focal drug‑resistant epilepsy.
Why this is a good match: Everolimus given after seizures for focal drug-resistant epilepsy in adults — directly therapeutic approach for refractory focal epilepsy.
Conditions:
Epilepsy, Drug Resistant, Everolimus, Focal Refractory Epilepsy, Epilepsy memory
PHASE2 ·
Icahn School of Medicine at Mount Sinai ·
NCT05019885
This study is testing if low doses of IV Ketamine can help people with drug-resistant epilepsy have fewer seizures and improve their mood.
Why this is a good match: Low-dose IV ketamine for drug-resistant epilepsy in adults — potential seizure and mood benefits for refractory patients.
Conditions:
Drug Resistant Epilepsy, Medically Refractory Epilepsy, Refractory Epilepsy, drug resistant epilepsy, subanesthetic Ketamine hydrochloride
NA ·
Xuanwu Hospital, Beijing ·
NCT06436547
This study is testing if deep brain stimulation can help people with drug-resistant temporal lobe epilepsy have fewer seizures.
Why this is a good match: Deep brain stimulation (DBS) for drug-resistant temporal lobe epilepsy — relevant for temporal-lobe refractory cases.
Conditions:
Epilepsy, Drug Resistant, Deep Brain Stimulation, Drug Resistant Epilepsy, Subiculum, Temporal lobe epilepsy with bilateral hippocampal sclerosis
NA ·
Xuanwu Hospital, Beijing ·
NCT06248333
This study is testing if deep brain stimulation can help people with drug-resistant focal motor epilepsy have fewer seizures compared to those who receive a fake treatment.
Why this is a good match: DBS for drug-resistant focal motor epilepsy — relevant if patient's seizures are focal motor in origin.
Conditions:
Epilepsy, Drug Resistant, Deep Brain Stimulation, Drug Resistant Epilepsy, Subthalamic Nucleus, Focal Motor Epilepsy
NA ·
First Affiliated Hospital Xi'an Jiaotong University ·
NCT05019404
This study tests a new, less invasive surgery for people with drug-resistant temporal lobe epilepsy to see if it can reduce seizures and improve their quality of life.
Why this is a good match: Less invasive surgery for drug-resistant temporal lobe epilepsy — therapeutic option for temporal-lobe epilepsy.
Conditions:
Temporal Lobe Epilepsy, Open Surgery, Minimally Invasive Surgery, Temporal lobe epilepsy, Anterior temporal lobectomy
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta ·
NCT06794606
This study is testing if surgery to remove the area of the brain causing seizures can help people with drug-resistant focal epilepsy feel better and have fewer seizures.
Why this is a good match: Surgical resection trial for drug‑resistant focal epilepsy — applicable if patient is a surgical candidate.
Conditions:
Epilepsy, Epilepsy surgery, drugs resistant focal epilepsy
National Institutes of Health Clinical Center (CC) ·
NCT01273129
This study is testing how well standard surgeries work for people aged 8 and older with epilepsy that doesn't get better with medication.
Why this is a good match: Study of outcomes after standard epilepsy surgeries in people 8+ — relevant for evaluating surgical options for refractory epilepsy.
Conditions:
Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy, Neurosurgery, Childhood Epilepsy
NA ·
Beth Israel Deaconess Medical Center ·
NCT07145489
This will try an infrared red-light therapy hat in adults with drug-resistant epilepsy to see if it reduces seizures and is comfortable to wear.
Why this is a good match: Infrared red‑light therapy hat for adults with drug‑resistant epilepsy — noninvasive therapeutic trial for refractory epilepsy.
Conditions:
Drug Resistant Epilepsy, epilepsy, photobiomodulation, seizure
NA ·
Dartmouth-Hitchcock Medical Center ·
NCT06425029
This test sees if daily listening to specific music through a web app can reduce epileptic brain activity in adults with medication‑resistant focal epilepsy who have an RNS implant.
Why this is a good match: Music-listening intervention for adults with medication‑resistant focal epilepsy who have RNS implants — therapeutic for a subset (RNS users).
Conditions:
Epilepsy, Refractory Epilepsy, Music, music, epilepsy
NA ·
University of California, Davis ·
NCT07580183
This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.
Why this is a good match: Research into memory and spatial recognition in temporal lobe epilepsy adults — diagnostic/phenotyping study relevant to temporal-lobe cases.
Conditions:
Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders, Epilepsy Comorbidities
NA ·
University of Michigan ·
NCT05928598
This study is testing a tablet tool called the 'Epilepsy Visit Planner' to see if it helps people with drug-resistant epilepsy communicate better with their doctors and improve their quality of life.
Why this is a good match: Epilepsy Visit Planner to improve communication and quality of life in drug-resistant epilepsy — supportive intervention for adults with refractory epilepsy.
Conditions:
Drug Resistant Epilepsy, Survey, Quality of life, Communication tool, Patient-provider communication
Epilepsy Foundation of America ·
NCT06265103
This study is trying to see if a new network can improve care and health outcomes for people with epilepsy by bringing together doctors, patients, and researchers to share and use health data.
Why this is a good match: Network-building study to improve epilepsy care/outcomes — systems-level relevance for ongoing care improvement.
Conditions:
Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases, Focal seizures
NA ·
Centre Hospitalier Universitaire, Amiens ·
NCT06212609
This study is testing a personalized brain stimulation treatment for children with hard-to-treat epilepsy to see if it can help control their seizures better.
Why this is a good match: Personalized brain stimulation in children with hard-to-treat epilepsy — therapeutic concept relevant but pediatric-specific.
Conditions:
Transcranial Electric Stimulation, tDCS, Epilepsy, Pharmacoresistant, HR EEG
['FUNDING_R21'] ·
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY ·
NIH-10989176
This study is looking at how seizures happen in epilepsy by examining how different parts of the brain work together, and it aims to create a new way to pinpoint the exact areas causing the seizures, which could help improve surgery options for people who don’t respond to medication.
Why this is a good match: Research developing methods to localize seizure sources to improve surgery for medication‑resistant patients — relevant for surgical planning.
