Zanubrutinib treatment for relapsed CNS lymphoma

Zanubrutinib Monotherapy in Relapsed/Refractory Central Nervous System Lymphoma

This study is testing if a new drug called zanubrutinib can help people with relapsed central nervous system lymphoma feel better and control their disease.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 20 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Peking University People's Hospital (Academic / other)
• Drugs / interventions: chemotherapy, radiation, Zanubrutinib, Ibrutinib
• Locations: 1 site (Beijing, Beijing)
• Trial ID: NCT05117814 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the efficacy of zanubrutinib, a novel BTK inhibitor, in patients with relapsed or refractory central nervous system lymphoma (CNSL). The study aims to evaluate the drug's ability to penetrate the CNS and its effectiveness in treating patients who have shown disease progression. Participants will receive zanubrutinib monotherapy, and their responses will be monitored through imaging and cytological assessments. The trial focuses on patients with documented disease progression and specific eligibility criteria to ensure a suitable candidate population.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with relapsed or refractory primary CNS lymphoma or secondary CNS lymphoma.

Not a fit: Patients with non-relapsed CNS lymphoma or those who do not meet the specific eligibility criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with difficult-to-treat CNS lymphomas.

How similar studies have performed: Previous studies with other BTK inhibitors like ibrutinib have shown promising results in similar patient populations, suggesting potential for zanubrutinib as well.

Eligibility criteria

Inclusion Criteria:

Key inclusion criteria:

1. Able to understand and willing to sign a written informed consent document
2. Men and woman at least 18 years of age on the day of consenting to the study
3. Histologically documented DLBCL.
4. Relapsed/refractory PCNSL or relapsed/refractory SCNSL
5. Patients with parenchymal lesions must have unequivocal evidence of disease progression on imaging (MRI or the brain or head CT) prior to study enrollment. For patients with leptomeningeal disease only, CSF cytology must document lymphoma cells and/or imaging findings consistent with CSF disease prior to study enrollment.
6. An ECOG performance status≤2
7. Adequate bone marrow and organ function shown by:

(1) Neutrophils ≥ 0.75 x 109/L independent of growth factor support within 7 days of study entry (2) Platelets ≥ 50 x 109/L independent of growth factor support or transfusion within 7 days of study entry (3) Creatinine clearance of ≥ 30 mL/min (4) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x upper limit of normal (ULN) (5) Bilirubin ≤ 1.5 x ULN (6) International normalized ratio ≤ 1.5 and activated partial thromboplastin time ≤ 1.5 x ULN.

8. Recovered to grade 1 toxicity from prior therapy before the first dose of study drug 9. Agree to use highly effective methods of birth control during the period of therapy and for 3 months after the last dose of the study drug.

Exclusion Criteria:

1. Patients with SCNSL actively receiving treatment for extra-CNS disease
2. Concurrently using other approved or investigational antineoplastic agents
3. Prior chemotherapy, targeted therapy, or radiation therapy within 4 weeks
4. Prior exposure to a BTK inhibitor
5. Concurrently using more than 8mg of dexamethasone daily or the equivalent
6. History of other active malignancies within 2 years of study entry
7. Major surgery within 4 weeks of screening or not recovered from the side effects of such surgery
8. Known to have human immunodeficiency virus (HIV) infection
9. Known to have a history of active or chronic infection with hepatitis C virus (HCV) or hepatitis B virus (HBV) as determined by serologic tests
10. Active infection systemic including infections requiring oral or intravenous antimicrobials
11. Currently active clinically significant cardiovascular disease
12. QTcF \> 480 msecs or other significant electrocardiogram (ECG) abnormalities
13. Unable to swallow capsules or disease significantly affecting gastrointestinal function
14. Any life-threatening illness, medical condition or organ system dysfunction which, in the investigator's opinion, could have compromised the patient's safety, or put the study at risk
15. Required ongoing treatment with medication that are strong cytochrome P450, family 3, subfamily A (CYP3A) inhibitors or strong CYP3A inducers
16. History of stroke or intracranial hemorrhage within 6 months prior to enrollment
17. Inability to comply with study procedures
18. Pregnant or lactating women
19. Prior allogenic hematopoietic stem cell transplantation (autologous stem cell transplant is NOT an exclusion)

Where this trial is running

Beijing, Beijing

• Peking University People's Hospital — Beijing, Beijing, China (Recruiting)

Study contacts

• Principal investigator: Shenmiao Yang, MD — Peking University Peoples' Hospital
• Study coordinator: Shenmiao Yang, MD

Conditions CNS Lymphoma; CNSL