Clinical trial Recruiting at 1 site Interventional Ages 24 Months to 18

Which fundoplication? Nissen vs Hil Snow for kids with GERD

Official title: the Effect of the Laparoscopic Management of Gastro Esophageal Reflux on Gastric Emptying in Pediatric Age Group

Run by Tanta University · NCT07708220 · Data updated 2026-11-12

In children with GERD, this trial tests two surgical options to see which one better preserves stomach emptying and reduces symptoms after anti-reflux surgery.

Quick facts

Study typeInterventional
Ages24 Months to 18 Years
SexAll
Enrollment36 (estimated)
SponsorTanta University
Academic / other
Locations1 site (Tanta)
StatusRecruiting
StartedMarch 1, 2025
Main results expectedAugust 1, 2026
Study endsOctober 1, 2026
Registry record updatedJuly 16, 2026
Trial IDNCT07708220 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Children aged 24 months to 18 years with GERD who have not had previous anti-reflux surgery and who are eligible for fundoplication.

Probably not a fit

Children with complex comorbidities or contraindications to either procedure may not experience benefit from the study interventions.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized trial compares Nissen fundoplication with the Hil Snow procedure in pediatric patients aged 24 months to 18 years undergoing anti-reflux surgery. Participants are assigned to one of the two surgical approaches at multiple tertiary pediatric centers. Outcomes include gastric emptying time, upper GI endoscopy findings, and post-surgical symptoms such as dysphagia, satiety, and discomfort. Data will be analyzed to identify which procedure yields better gastric function and symptom control after fundoplication.

Why it matters

Potential benefit: If successful, the study could guide surgeons toward the procedure that offers better gastric emptying and fewer digestive symptoms in children with GERD.

How similar studies have gone: Prior work in adults and pediatric surgical literature shows mixed results; this study addresses a gap with direct pediatric randomization between two techniques.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* all children with GERD above the age of 24 months until 18 years

Exclusion Criteria:

* previous antireflux surgery
* previous exploration
* Esophageal atresia congenital diaphragmatic hernia omphalocele major

Where it's running

  • Faculty of Medicine
    Tanta, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Browse more
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.