When to do coronary angiography for NSTEMI with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional trial assigns adults with NSTEMI and acute decompensated heart failure to either immediate coronary angiography (within 2 hours of diagnosis) or delayed angiography after clinical stabilization. The primary endpoint is a composite of all-cause death, non-fatal myocardial infarction, or hospitalization for heart failure at 12 months. Key exclusion criteria include cardiogenic shock at presentation, ST-elevation MI, recent or planned CABG, life-threatening arrhythmias, non-ischemic causes of heart failure, pregnancy, and life expectancy under one year. The trial is led by Chonnam National University Hospital and enrolls patients at multiple tertiary centers in South Korea.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥19 years
* Non-ST-segment elevation myocardial infarction
* New-onset or worsening of dyspnea (New York Heart Association class ≥2)
* Pulmonary congestion
* Patient's or guardian's consent after understanding the study

Exclusion Criteria:

* Cardiogenic shock at initial presentation
* ST-segment elevation myocardial infarction

  * ST-segment elevation ≥0.1 mV in at least 2 contiguous leads, or
  * New onset left bundle branch block
  * Posterior wall myocardial infarction
* Refractory angina
* Life threatening ventricular arrhythmias
* Life expectancy \<1 year
* Apparently non-ischemic cause of HF
* Pregnancy and lactation
* History of coronary artery bypass grafting (CABG), or planned CABG
* Patient's refusal to participate in study

Where it's running

• Gyeongsang National University Changwon Hospital
  Changwon, South Korea Recruiting
• Keimyung University Dongsan Hospital
  Daegu, South Korea Recruiting
• Yeongnam University Medical Center
  Daegu, South Korea Recruiting
• Chungnam National University Hospital
  Daejeon, South Korea Recruiting
• Chonnam National University Hospital
  Gwangju, South Korea Recruiting
• Gwangju Veterans Hospital
  Gwangju, South Korea Recruiting

Study contacts

• Study coordinator: Youngkeun Ahn, Professor
• Email: cecilyk@hanmail.net
• Phone: 82-62-220-4764

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.