Weight loss surgery before knee replacement for obese patients
Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
This study tests if having weight loss surgery before knee replacement helps obese patients with severe knee arthritis recover better and have fewer problems after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Nova Scotia Health Authority Academic / other |
| Locations | 1 site (Halifax, Nova Scotia) |
| Trial ID | NCT05120492 on ClinicalTrials.gov |
What this trial studies
This trial investigates whether undergoing weight loss surgery prior to total knee replacement improves surgical outcomes for patients with severe knee osteoarthritis and a body mass index (BMI) between 45 and 60. Participants are randomly assigned to either receive dietary and lifestyle counseling followed by knee replacement or to undergo sleeve gastrectomy followed by the same knee replacement procedure. The study aims to assess the feasibility and effectiveness of this approach over a period of 9 to 13 months.
Who should consider this trial
Good fit: Ideal candidates are individuals with severe knee osteoarthritis and a BMI between 45 and 60.
Not a fit: Patients who have previously undergone knee replacement surgery or have significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved recovery and outcomes for patients undergoing knee replacement surgery.
How similar studies have performed: While this approach is innovative, similar studies have shown promising results in improving outcomes for obese patients undergoing orthopedic surgeries.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: severe knee osteoarthritis body-mass index of 45 to 60 Exclusion Criteria: previous total replacement of the same knee, a need for bilateral total knee replacement, and knee pain during the previous week that the patient rated at higher than 60 mm on a 100-mm visual-analogue scale. Also,prior bariatric or complex foregut surgery, significant cardiovascular, pulmonary, renal, liver, gastrointestinal, psychiatric disorders, pregnancy, malignancy within last 5 years, anemia, coagulopathy requiring anti-coagulation therapy.
Where this trial is running
Halifax, Nova Scotia
- Nova Scotia Health — Halifax, Nova Scotia, Canada (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.