Weight loss surgery before knee replacement for obese patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates whether undergoing weight loss surgery prior to total knee replacement improves surgical outcomes for patients with severe knee osteoarthritis and a body mass index (BMI) between 45 and 60. Participants are randomly assigned to either receive dietary and lifestyle counseling followed by knee replacement or to undergo sleeve gastrectomy followed by the same knee replacement procedure. The study aims to assess the feasibility and effectiveness of this approach over a period of 9 to 13 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

severe knee osteoarthritis body-mass index of 45 to 60

Exclusion Criteria:

previous total replacement of the same knee, a need for bilateral total knee replacement, and knee pain during the previous week that the patient rated at higher than 60 mm on a 100-mm visual-analogue scale. Also,prior bariatric or complex foregut surgery, significant cardiovascular, pulmonary, renal, liver, gastrointestinal, psychiatric disorders, pregnancy, malignancy within last 5 years, anemia, coagulopathy requiring anti-coagulation therapy.

Where it's running

• Nova Scotia Health
  Halifax, Nova Scotia, Canada Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.