Web-based cognitive behavioral therapy for cancer-related fatigue
Making Cognitive Behavioral Therapy for Cancer-related Fatigue Fit for Implementation in Patients With Cancer Receiving Palliative Systemic Treatment
This study is testing whether an online therapy program can help cancer patients with severe fatigue just as much as in-person therapy does.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy, radiation |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT06511518 on ClinicalTrials.gov |
What this trial studies
This study aims to integrate interdisciplinary web-based cognitive behavioral therapy (inter-CBT) into clinical practice for patients with cancer receiving palliative treatment. It seeks to demonstrate that inter-CBT is non-inferior to traditional face-to-face cognitive behavioral therapy in reducing severe fatigue, a common and burdensome symptom in this patient population. The study will involve patients who are undergoing systemic treatment for solid tumors and experiencing significant fatigue, with the goal of improving their quality of life through a more accessible intervention.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are receiving palliative systemic treatment for solid tumors and report severe fatigue.
Not a fit: Patients with symptomatic brain metastases, poor performance status, or those currently receiving treatment for a mental disorder may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce cancer-related fatigue and improve the quality of life for patients undergoing palliative treatment.
How similar studies have performed: Previous studies have shown that cognitive behavioral therapy can effectively reduce fatigue in cancer patients, but this web-based approach is a novel integration into routine care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Receive systemic treatment with palliative intent for a solid tumor. * Treatments include chemotherapy, targeted therapy, immunotherapy, and hormone therapy, possibly combined with surgery and/or radiation therapy * Are ≥18 years old * Are proficient in Dutch * Report severe fatigue (Checklist Individual Strength, fatigue severity subscale \[CIS-fatigue\] score ≥35) with no known somatic explanation other than cancer and/or cancer treatment * A life expectancy of ≥6 months according to their oncologist * Access to a device with internet. Exclusion Criteria: * Symptomatic brain metastases * Have a poor performance status (Karnofsky \<70) * Are currently receiving treatment for a mental disorder.
Where this trial is running
Amsterdam, North Holland
- Medical Psychology — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Hans Knoop, Prof.
- Email: hans.knoop@amsterdamumc.nl
- Phone: 020 5666932
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.