Web-based cognitive behavioral therapy for cancer-related fatigue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to integrate interdisciplinary web-based cognitive behavioral therapy (inter-CBT) into clinical practice for patients with cancer receiving palliative treatment. It seeks to demonstrate that inter-CBT is non-inferior to traditional face-to-face cognitive behavioral therapy in reducing severe fatigue, a common and burdensome symptom in this patient population. The study will involve patients who are undergoing systemic treatment for solid tumors and experiencing significant fatigue, with the goal of improving their quality of life through a more accessible intervention.

Why it matters

Who can join: the full rules

Solid (non-brain) tumor patients

Inclusion Criteria:

* Receive systemic treatment with palliative intent for a solid (non-brain) tumor
* Are ≥18 years old
* Are proficient in Dutch
* Report severe fatigue (Checklist Individual Strength, fatigue severity subscale \[CIS-fatigue\] score ≥35)
* A life expectancy of ≥6 months according to their oncologist
* Access to a device with internet

Exclusion Criteria:

* Symptomatic brain metastases
* Dual immunotherapy
* Have a poor performance status (Karnofsky \<70)
* Are currently receiving treatment for a mental disorder.
* Treatable somatic cause that could explain the presence of severe fatigue (other than the underlying disease and the cancer treatment itself)
* Severe cognitive deficits

Glioma patients

Inclusion Criteria:

* Histologically confirmed diffuse glioma WHO grade 2, 3, or 4
* No oncological treatment for at least two months prior to inclusion
* Are ≥18 years old
* Are proficient in Dutch
* Report severe fatigue (Checklist Individual Strength, fatigue severity subscale \[CIS-fatigue\] score ≥35)
* A life expectancy of ≥3 months according to their oncologist
* Access to a device with internet

Exclusion Criteria:

* Signs of radiological or clinical tumor progression at the time of inclusion
* Corticosteroid use
* Have a poor performance status (Karnofsky \<70)
* Are currently receiving treatment for a mental disorder
* Treatable somatic cause that could explain the presence of severe fatigue (other than the underlying disease and the cancer treatment itself).
* Severe cognitive deficits

Where it's running

• Medical Psychology
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Hans Knoop, Prof.
• Email: hans.knoop@amsterdamumc.nl
• Phone: 020 5666932

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.