Wearable Smart Underwear to Measure Gut Hydrogen Sulfide Production
Employing Smart Underwear to Measure Gut Microbial Hydrogen Sulfide Production
This study is testing a new type of smart underwear that measures gas produced by the gut to see how different diets affect gut health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Aurora, Colorado) |
| Trial ID | NCT06802276 on ClinicalTrials.gov |
What this trial studies
This study evaluates a prototype of Smart Underwear designed to measure changes in gut microbial hydrogen sulfide (H₂S) production in response to different diets. Participants will undergo a crossover feeding design with two isocaloric diets, one high in cysteine and the other low, over a series of 6-day periods. The Smart Underwear utilizes advanced gas sensors to provide real-time, non-invasive measurements of H₂S in flatus, addressing limitations of current measurement techniques. The goal is to better understand the relationship between diet, gut microbiome, and health outcomes related to H₂S production.
Who should consider this trial
Good fit: Ideal candidates are generally healthy adults over 18 years old with normal bowel movements and no major health conditions.
Not a fit: Patients with significant health conditions such as diabetes, cancer, or gastrointestinal diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of diseases linked to gut microbial H₂S production.
How similar studies have performed: While the approach of using wearable technology for measuring gut microbial production is innovative, similar studies have not been widely conducted, making this a novel exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
The inclusion/exclusion criteria will identify generally healthy volunteers that are able to ingest the intervention diets. Exclusion criteria based on diseases, medications, allergies, and specific dietary requirements will minimize the risks of adverse reactions to the intervention diets. Inclusion Criteria: * Generally healthy volunteers defined as having no major known health conditions (e.g., diabetes, cancer, hypertension, etc.). * Normal bowel movements, with approximately 1 bowel movement reported per day * Willing to discuss flatus * Ages \>18yrs * Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements. Exclusion Criteria: * Self-report or other evidence of diabetes, other endocrine/metabolic abnormality, dyslipidemia, morbid obesity, severe hypertension, chronic kidney disease, liver disease, pulmonary disease, gastrointestinal, and cardiovascular diseases * Chronic medications for any of the above conditions * Food allergy that interferes with ability to complete the study * Food preferences, intolerance, or dietary requirements that would interfere with diet adherence * Planned dietary changes during the study period * Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave) * Pregnancy or planned pregnancy in the next month * Physical measurements: BMI \> 35 kg/m2
Where this trial is running
Aurora, Colorado
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (Recruiting)
Study contacts
- Principal investigator: Noel T Mueller, PhD — University of Colorado, Denver
- Study coordinator: Noel T Mueller, PhD
- Email: noel.mueller@cuanschutz.edu
- Phone: 414-779-1167
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.