We Are Here Now Plus: a culturally centered program to improve sexual, mental, and substance health for American Indian youth

Nen ŨnkUmbi/EdaHiYedo Plus (NE+): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth

Not applicable Interventional Montana State University · NCT07460973

This project tests a 9-month, culturally grounded program for American Indian youth ages 12–18 to try to reduce substance use during sex, increase condom use, and improve mental health and communication with caregivers and schools.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment843 (estimated)
Ages12 Years to 18 Years
SexAll
SponsorMontana State University Academic / other
Locations1 site (Bozeman, Montana)
Trial IDNCT07460973 on ClinicalTrials.gov

What this trial studies

This is a two-arm intervention comparing a culturally tailored 9-month curriculum (NE+) to a control arm among American Indian adolescents living on the Fort Peck Reservation. Youth participants aged 12–18 receive 18 educational modules covering healthy relationships, puberty (separate sessions for girls and boys), parenting, pregnancy and STI/HIV prevention, and substance-use topics. The trial measures behavioral outcomes such as substance use during sex, sexual activity, condom use, mental health status, caregiver-youth and school-youth communication, and use of clinical services at baseline and follow-up. Enrollment is limited to enrolled or associate members of federally recognized tribes who live on the Fort Peck Reservation and have caregiver permission to participate.

Who should consider this trial

Good fit: Ideal candidates are 12–18-year-old enrolled or associate members of a federally recognized tribe who reside on the Fort Peck Reservation and have a caregiver willing to provide permission for participation.

Not a fit: Youth outside the 12–18 age range, those who are not tribal members or do not live on the Fort Peck Reservation, or those with cognitive or physical impairments that prevent participation likely would not benefit from this intervention.

Why it matters

Potential benefit: If successful, NE+ could lower risky sexual behavior and substance use while improving mental health and care-seeking among participating American Indian youth.

How similar studies have performed: Culturally grounded, multilevel interventions for Indigenous youth have shown promising but mixed results in prior work, with rigorous evidence still limited.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 12 to 18 years old
* Registered member of a federally recognized tribe or an associate tribal member
* Resident of the Fort Peck Reservation with a caregiver who agrees for their child to participate in the intervention

Exclusion Criteria:

* Not meeting any of the aforementioned inclusion criteria
* Having a medically identified physical or cognitive impairment that would impede their understanding of and participation in the educational content, activities, and teachings of the intervention

Where this trial is running

Bozeman, Montana

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions HealthyCondom UseMental HealthSubstance UseSexual and reproductive healthMental healthSubstance use
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.