VVI index to predict success of getting off a ventilator
Official title: External Validation of the Volume-Velocity Index for Weaning Prediction: a Multicenter Observational Study
Run by University of Thessaly · NCT07372664 · Data updated 2026-11-12
This will test whether the volume-velocity index (VVI), measured from diaphragm movement and breathing patterns, can predict which ventilated patients ready for a first weaning attempt will be successfully liberated.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Thessaly Academic / other |
| Locations | 3 sites (Larissa and 2 other locations) |
| Status | Recruiting |
| Started | December 28, 2025 |
| Main results expected | August 2027 |
| Study ends | September 2027 |
| Registry record updated | September 2, 2026 |
| Trial ID | NCT07372664 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults mechanically ventilated for more than 48 hours who are undergoing their first spontaneous breathing trial and are judged ready to wean by their treating physician using published readiness criteria.
✕Probably not a fit
Patients who are pregnant, have preexisting diaphragmatic disease or injury, have a tracheostomy, or are not undergoing a first spontaneous breathing trial are excluded and would not benefit from this validation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study enrolls adults mechanically ventilated for more than 48 hours who are judged ready for their first spontaneous breathing trial. Investigators will measure diaphragm excursion by ultrasound and record inspiratory time, tidal volume, and per-breath volume to calculate the volume-velocity index (VVI). Measurements will be taken in three common weaning settings (pressure support 5/5, pressure support 8/0, and T-piece or PSV 0/0) and patients will be followed to determine weaning success or failure. The aim is to externally validate a previously reported predictive index by comparing VVI results to actual liberation outcomes.
Why it matters
Potential benefit: If successful, the VVI could help clinicians identify patients who can be safely taken off mechanical ventilation sooner, reducing ventilation days, complications, and length of stay.
How similar studies have gone: A preliminary internal study reported high accuracy for the VVI, and other diaphragm-ultrasound indices have shown promise, but external validation remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mechanically ventilated patients for more than 48h * First Spontaneous breathing trial * Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183/09031936.00010206) Exclusion Criteria: * pregnant patients * preexisting diaphragmatic disease or injury * tracheostomy
Where it's running
-
General University Hospital of Larissa
Larissa, Greece Recruiting -
AHEPA - University General Hospital
Thessaloniki, Greece Not yet recruiting -
General Hospital of Thessaloniki "G. Papanikolaou"
Thessaloniki, Greece Not yet recruiting
Study contacts
- Principal investigator: Apostolos - Alkiviadis Menis — General Hospital of Larissa
- Study coordinator: Apostolos - Alkiviadis Menis, MD, PhD
- Email: menis.ap.alk@gmail.com
- Phone: +30 2413501280
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.