Virtual reality training for left-sided neglect after right-hemisphere stroke
The Effects of Virtual Reality-based Training for the Treatment of Neglect Syndrome in Stroke: a Randomized Controlled Trial
NA · Yonsei University · NCT07102927
We will test whether virtual reality training helps adults with left-sided neglect after a right-hemisphere stroke who are at least three months post-stroke.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 19 Years to 99 Years |
| Sex | All |
| Sponsor | Yonsei University (other) |
| Locations | 1 site (Seoul) |
| Trial ID | NCT07102927 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial compares a virtual reality-based training program with conventional occupational therapy in people with unilateral neglect in the chronic phase after right-hemisphere stroke. Eligible participants are adults (≥19 years) with left hemiplegia and neglect confirmed by the Behavioral Inattention Test, and who have sufficient cognition for VR participation (MMSE > 18). The study excludes patients with hemianopsia, major visual or hearing impairments, significant neck problems, inability to sit with support, other conditions affecting cognition, or recurrent cybersickness. Outcomes will measure changes in neglect severity and functional abilities to explore potential mechanisms of recovery.
Who should consider this trial
Good fit: Adults aged 19 or older with a right-hemisphere stroke at least three months earlier, left hemiplegia, BIT scores indicating unilateral neglect, and MMSE > 18 are the ideal candidates.
Not a fit: Patients with hemianopsia, severe cognitive decline, major visual or hearing loss, inability to maintain a seated posture, or who cannot tolerate VR due to cybersickness are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the VR program could improve attention to the neglected side and lead to better performance in daily activities like dressing, eating, and safe navigation.
How similar studies have performed: Previous approaches such as visuo-spatial scanning training and computer-based therapy (reported by Pizzamiglio and Julkunen) have shown promising improvements in neglect, so this VR approach builds on those positive findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Patients diagnosed with right cerebral hemisphere stroke confirmed by MRI or CT, with left hemiplegia, and at least three months post-stroke 2. Patients confirmed to have unilateral neglect based on the BIT score (total BIT score ≤ 196, or subtest scores BITC ≤ 129 or BITB ≤ 67) 3. Individuals with sufficient cognitive ability to participate in virtual reality training (MMSE \> 18) 4. Adults aged 19 years or older Exclusion Criteria: * 1\. Presence of Hemianopsia 2. Impaired neck movement due to orthopedic issues or other causes 3. Visual or hearing impairments that interfere with evaluation and treatment 4. Difficulty maintaining a seating posture in a chair with a backrest and armrests 5. Presence of other medical issues that may affect general cognitive decline 6. Experiencing Cybersickness symptoms such as nausea, vomiting, eye strain, disorientation, ataxia, or dizziness repeatedly, making continued training difficult and requiring discontinuation as determined by the researcher
Where this trial is running
Seoul
- Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine — Seoul, South Korea (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Cognitive Dysfunction, Unilateral Neglect Syndrome