Virtual reality training for left-sided neglect after right-hemisphere stroke
Official title: The Effects of Virtual Reality-based Training for the Treatment of Neglect Syndrome in Stroke: a Randomized Controlled Trial
Run by Yonsei University · NCT07102927 · Data updated 2026-11-12
We will test whether virtual reality training helps adults with left-sided neglect after a right-hemisphere stroke who are at least three months post-stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years to 99 Years |
| Sex | All |
| Enrollment | 28 (estimated) |
| Sponsor | Yonsei University Academic / other |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | September 22, 2022 |
| Main results expected | December 2025 |
| Study ends | December 2026 |
| Registry record updated | August 5, 2025 |
| Trial ID | NCT07102927 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 19 or older with a right-hemisphere stroke at least three months earlier, left hemiplegia, BIT scores indicating unilateral neglect, and MMSE > 18 are the ideal candidates.
✕Probably not a fit
Patients with hemianopsia, severe cognitive decline, major visual or hearing loss, inability to maintain a seated posture, or who cannot tolerate VR due to cybersickness are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares a virtual reality-based training program with conventional occupational therapy in people with unilateral neglect in the chronic phase after right-hemisphere stroke. Eligible participants are adults (≥19 years) with left hemiplegia and neglect confirmed by the Behavioral Inattention Test, and who have sufficient cognition for VR participation (MMSE > 18). The study excludes patients with hemianopsia, major visual or hearing impairments, significant neck problems, inability to sit with support, other conditions affecting cognition, or recurrent cybersickness. Outcomes will measure changes in neglect severity and functional abilities to explore potential mechanisms of recovery.
Why it matters
Potential benefit: If successful, the VR program could improve attention to the neglected side and lead to better performance in daily activities like dressing, eating, and safe navigation.
How similar studies have gone: Previous approaches such as visuo-spatial scanning training and computer-based therapy (reported by Pizzamiglio and Julkunen) have shown promising improvements in neglect, so this VR approach builds on those positive findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Patients diagnosed with right cerebral hemisphere stroke confirmed by MRI or CT, with left hemiplegia, and at least three months post-stroke 2. Patients confirmed to have unilateral neglect based on the BIT score (total BIT score ≤ 196, or subtest scores BITC ≤ 129 or BITB ≤ 67) 3. Individuals with sufficient cognitive ability to participate in virtual reality training (MMSE \> 18) 4. Adults aged 19 years or older Exclusion Criteria: * 1\. Presence of Hemianopsia 2. Impaired neck movement due to orthopedic issues or other causes 3. Visual or hearing impairments that interfere with evaluation and treatment 4. Difficulty maintaining a seating posture in a chair with a backrest and armrests 5. Presence of other medical issues that may affect general cognitive decline 6. Experiencing Cybersickness symptoms such as nausea, vomiting, eye strain, disorientation, ataxia, or dizziness repeatedly, making continued training difficult and requiring discontinuation as determined by the researcher
Where it's running
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Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine
Seoul, South Korea Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.