Virtual home-based exercise program for kidney transplant candidates

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the feasibility of a 12-week virtual pre-habilitation intervention that includes exercise and education for individuals awaiting kidney transplants. Participants will engage in a structured program designed to enhance their physical health and functional capacity before surgery, followed by a 5-month maintenance phase of independent home exercises. The study will assess eligibility rates, consent rates, adherence to the intervention, follow-up completion, and overall acceptability of the program among participants. The control group will receive standard outpatient care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* consecutive individuals with end stage kidney disease (ESKD) (aged ≥18 years), classified as pre-frail (1-2 points), frail (3-4 points) or very frail (5 points) on the Fried's frailty phenotype and who are accepted or in the process of being accepted to enter in the deceased or living donor KT waiting list of the McGill University Health Centre (MUHC), Centre Hospitalier de l'Université de Montreal (CHUM) or University of Alberta Hospital (UAH) for first-time transplantation or re-transplantation
* English or French speakers
* is technologically capable of connecting (either independently or through household members/next-of-kin) with an online videoconferencing platform through an e-mail invitation (Patients who do not have access to internet will borrow a tablet with internet for the period of the study)

Exclusion Criteria:

* Individuals who:
* are classified as robust (0 points) on their Fried's frailty phenotype score
* are participating in a structured exercise program (hospital-based or home-based or another trial)
* are waiting for kidney-pancreas or kidney-liver transplant as those have much longer waiting time
* are hospitalized for any reason during the assessment for eligibility
* have a cPRA (calculated panel reactive antibodies) \>95% and are on the highly sensitized exchange program and expected to have a prolonged waiting times on the waiting list
* are expected to have a transplant before the end of the 12 week-intervention (e.g. individuals who will receive an organ from a living donor or are type A blood
* have pre-existing or newly identified significant cognitive impairment
* have pre-existing or newly identified cardiac, musculoskeletal, neuropathy or neurological condition that might affect their exercise performance or otherwise render rehabilitation participation unsafe

Where it's running

• Centre de recherche - Centre Hospitalier de l'Université de Montréal (CRCHUM)
  Montreal, Quebec, Canada Recruiting
• Research Institute - McGill University Health Centre (RI-MUHC)
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Tania Janaudis-Ferreira, PhD — Research Institute of McGill University Health Centre (RI-MUHC)
• Study coordinator: Tania Janaudis-Ferreira, PhD
• Email: tania.janaudis-ferreira@mcgill.ca
• Phone: 514-619-0871

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.