Venous congestion and delirium after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort will enroll adults having elective cardiac surgery via a midline thoracic incision and monitor venous congestion with intraoperative transesophageal echocardiography (TEE) alongside routine hemodynamic and laboratory measures. Investigators will collect demographics, comorbidities, surgery parameters, serial hemodynamic data, biological labs, and standardized postoperative delirium assessments. Patients must have a preoperative MMSE > 23 and be able to cooperate with cognitive testing; those with contraindications to TEE or major preoperative instability are excluded. The analysis will correlate markers of systemic and hepatic/portal venous congestion (for example IVC dilation and abnormal venous flow signals) with the incidence and timing of postoperative delirium.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision;
2. ≥18 years;
3. A preoperative MMSE score\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function.

Exclusion Criteria:

1. Contraindications for TEE;
2. Emergency cardiac surgery;
3. Major vascular surgery;
4. Redo cardiac surgery;
5. Severe infection requiring continuous antibiotic therapy;
6. Severe preoperative heart failure with left ventricular ejection fraction \< 30%;
7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitating resuscitation);
8. Multi-organ dysfunction;
9. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow (such as urinary tract obstruction);
10. Planned cardiac transplantation or ventricular assist device implantation;
11. Pregnancy;
12. Insufficient ultrasonographic imaging;
13. Restarting CPB after first CPB cessation during surgery;
14. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively;
15. Neurological or psychiatric diagnoses that may affect cognitive performance or cognitive testing;
16. Documented delirium before surgery.

Where it's running

• No. 368 Hanjiang Middle Road
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Zhuan Zhang, MD — The Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou University
• Study coordinator: Zhuan Zhang, MD
• Email: zhangzhuancg@163.com
• Phone: +8615062791355

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Guided fluid removal using VeXUS score for patients with acute kidney injury after heart surgery

  This study is testing if using the VeXUS score to manage fluid levels can help patients with acute kidney injury after heart surgery recover better than standard care.

  Recruiting Hospices Civils de Lyon · Bron, Bron and 1 other locations · NCT06251713

• Impact of Fast-Track Anesthesia on Postoperative Delirium After Cardiac Surgery

  This observational study tests whether fast-track anesthesia, compared with conventional care, is linked to lower rates of delirium after elective cardiac surgery in adults.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT07923344

• Sarcopenia in Patients After Cardiac Surgery

  This observational study tests how common sarcopenia is after cardiac surgery and whether current care helps improve muscle mass and function.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07908472

• Lower pressure during laparoscopic surgery to prevent delirium in older adults

  In adults aged 60 and up having laparoscopic pelvic surgery, the study tests whether using a lower-than-usual intraabdominal pressure during the operation reduces postoperative delirium.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07906444

• Immunonutrition and Brain Monitoring to See if Delirium Happens After Gynecologic Cancer Surgery

  This study tests whether a preoperative immunonutrition scoring plus intraoperative brain monitoring can help predict or relate to postoperative delirium in women aged 65 and older undergoing major gynecologic cancer surgery.

  Recruiting Elazıg Fethi Sekin Sehir Hastanesi · Elâzığ, Elâzığ · NCT07877285

• Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery

  This study will see if certain biomarkers like melatonin and serotonin can predict delirium in adults 65+ after abdominal cancer surgery.

  Recruiting Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Istanbul, Istanbul · NCT07859488

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.