Validation of questionnaires for chronic rhinosinusitis severity and control

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project involves a collaboration of 32 medical centers across Europe, the USA, and South Africa to validate two new questionnaires designed to assess the self-perceived severity and control of chronic rhinosinusitis (CRS) with and without nasal polyps. The study aims to recruit 1000 patients from routine ENT practices to ensure a straightforward data collection process. The statistical analysis and report creation will be managed by the University of Leuven's statistical department, comparing the new questionnaires with existing assessment tools.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient capable of giving informed consent
* Diagnosis of chronic rhinosinusitis with or without nasal polyposis according to the EPOS guidelines
* No recent sinus surgery (within the last three months)

Exclusion Criteria:

* Not capable of giving informed consent
* No CRS
* Recent sinus surgery (within the last three months)

Where it's running

• UCLA Santa Monica Medical Center
  Santa Monica, California, United States Recruiting
• Northwestern University Feinberg School of Medicine
  Chicago, Illinois, United States Recruiting
• Brigham Sinus Center at Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting
• Thomas Jefferson University Hospital
  Philadelphia, Pennsylvania, United States Recruiting
• Eastern Virginia Medical School
  Virginia City, Virginia, United States Recruiting
• UZ Leuven
  Leuven, Belgium Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Airiver Balloon Dilation added to endoscopic sinus surgery for chronic rhinosinusitis with or without nasal polyps

  This study tests whether adding a paclitaxel-coated balloon dilation to endoscopic sinus surgery helps adults with chronic rhinosinusitis, with or without nasal polyps, at up to 40 US sites.

  Recruiting at 16 sites Airiver Medical, Inc. · Birmingham, Alabama and 15 other locations · NCT07290140

• Sinonasal microbiome transplant for chronic rhinosinusitis

  This will try a sinonasal microbiome transplant to see if it reduces symptoms in people with chronic rhinosinusitis with or without nasal polyps.

  Recruiting Phase 2/3 Region Skane · Helsingborg · NCT07184684

• OPN-375 (fluticasone) nasal spray twice daily for teens with chronic rhinosinusitis without nasal polyps

  This study will test whether OPN-375 nasal spray (186 µg) given twice daily helps adolescents (12–17) with chronic rhinosinusitis without nasal polyps have fewer symptoms than placebo.

  Recruiting at 19 sites Phase 3 Optinose US Inc. · Huntsville, Alabama and 23 other locations · NCT06850805

• Investigating the effects of Dupilumab on nasal barrier function in chronic rhinosinusitis patients

  This study is testing if the medication Dupilumab can improve the nasal barrier function in people with chronic rhinosinusitis, especially those with nasal polyps.

  Recruiting Medical University of Vienna · Vienna, Austria · NCT06398873

• Using 3D printing to enhance nasal irrigation for chronic rhinosinusitis

  This study is testing if 3D printed models of patients' noses can help people with chronic rhinosinusitis use nasal irrigation more effectively and feel better without surgery.

  Recruiting Ohio State University · Columbus, Ohio · NCT06118554

• Mepolizumab with or without in-office nasal polypectomy for chronic rhinosinusitis with nasal polyps

  This study tests whether adding mepolizumab, alone or with in-office nasal polypectomy, helps adults with chronic rhinosinusitis with nasal polyps who need biologic treatment.

  Recruiting at 7 sites Phase 4 Instituto de Investigación Marqués de Valdecilla · Barakaldo and 6 other locations · NCT07814924

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.