Vaccinations to protect frail patients from pneumococcus, shingles, flu, hepatitis B, and COVID-19
Official title: Caring for Frail Patients Through Vaccination
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06127563 · Data updated 2026-11-12
This project uses hospital records to find frail adults who may be missing recommended vaccines and contacts them to offer pneumococcal, zoster, influenza, hepatitis B, and COVID-19 vaccination.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome, Lazio) |
| Status | Recruiting |
| Started | July 17, 2024 |
| Main results expected | July 17, 2026 |
| Study ends | July 17, 2027 |
| Registry record updated | August 12, 2025 |
| Trial ID | NCT06127563 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who have attended Dermatology, Oncological Gynecology, Geriatrics, Nephrology, or Gastroenterology at Fondazione Policlinico Universitario A. Gemelli IRCCS and have medical residence in the Lazio region are the intended candidates.
✕Probably not a fit
Patients already up to date with the recommended vaccines, those living outside the Lazio region, those who do not attend the listed departments, or those who decline contact/consent are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The project applies an automated algorithm to electronic health records and the regional vaccination registry to identify adults seen in selected departments who are missing recommended vaccines. Consenting eligible patients will be contacted in hospital, by message, or by email and offered enrollment in a clinical pathway to increase vaccination coverage. The pathway targets pneumococcal, zoster, influenza, hepatitis B, and SARS-CoV-2 vaccines and follows the national vaccination plan and recent Ministry of Health guidance. Expected outcomes include higher vaccine uptake among frail patients and fewer vaccine-preventable complications requiring hospital care.
Why it matters
Potential benefit: If successful, this approach could raise vaccine coverage in frail patients and reduce hospital stays, long-term complications, and deaths from these infections.
How similar studies have gone: Electronic health record–based identification and outreach programs have previously improved adult vaccine uptake in other settings, although targeting frail inpatient populations is less extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old or more, * Patients who have accessed one of the enrolled departments (Dermatology, Oncological gynaecology, Geriatry, Nephrology, Gastroenterology), * Medical residence in Lazio Region Exclusion Criteria: \- Patients who do not fulfill 1 or more inclusion criteria
Where it's running
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Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Lazio, Italy Recruiting
Study contacts
- Principal investigator: Patrizia Laurenti — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Study coordinator: Patrizia Laurenti
- Email: patrizia.laurenti@policlinicogemelli.it
- Phone: +390630155701
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.