UV-treated dental implants with or without melatonin in the upper back jaw

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the clinical and radiographic outcomes of photofunctionalized (UV-treated) dental implants, with and without melatonin, placed in the posterior maxilla. It focuses on regions with potentially poorer bone quality and aims to see whether UV treatment improves primary and secondary stability and osseointegration. The trial plans to enroll 21 implants in adults needing tooth replacement, comparing three approaches that include UV-treated implants and conventional implants, with and without melatonin. Surface modification via UV photofunctionalization is intended to enhance hydrophilicity, protein adsorption, and osteoblast activity, while melatonin is studied for its anti-inflammatory, antioxidant effects and potential to reduce bone resorption. Outcomes will be assessed clinically and radiographically over the healing period to determine potential synergistic benefits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 60 years old.
* Patients seeking replacement of missed single or multiple teeth in the posterior maxilla.
* Sufficient bone volume (height and width) to accommodate dental implant placement without major bone grafting.
* Good oral hygiene and motivated patients.
* Systemically healthy patients with no contraindications for minor oral surgery.

Exclusion Criteria:

* Patients with uncontrolled systemic diseases
* Patients who received radiation therapy in the head and neck region within the last 5 years.
* Heavy smokers (more than 10 cigarettes per day).
* Patients with active periodontal disease or poor oral hygiene.
* Pregnant or lactating females.
* Parafunctional habits such as severe bruxism or clenching.

Where it's running

• Faculty of Dentistry, Mansoura University
  Al Mansurah, Dakahlia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Ali K Ali, BDS
• Email: ak3605773@gmail.com
• Phone: 00201553005571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.