Using Y90-PET-CT scans after liver cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with liver cancer or liver metastasis undergoing Y90 radioembolisation therapy, where yttrium-90 microspheres are infused into the liver to target tumors. The primary goal is to introduce and optimize a Y90-PET-CT scanning protocol to assess the delivery of the radioactive treatment to the target lesions. By comparing the quality of images obtained from Y90-PET-CT scans to traditional Y90-bremsstrahlung-SPECT scans, the study aims to provide more accurate information regarding the success of the therapy. Additionally, the study will implement post-therapy dosimetry using the optimized imaging to enhance patient management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing liver treatment Y90-Microspheres therapy.
* Male or female
* Aged 18-85 years

Exclusion Criteria:

A participant will not be eligible for inclusion in this study if any of the following criteria apply:

* History of, or suffers from, claustrophobia or participant feels unable to lie flat and still on their back for a period of up to 45 minutes in the scanner;

  o Priority will be given to their current clinical care scan Y-90-bremsstrahlung-SPECT
* In the opinion of the clinical team, they are unlikely to comply with the study protocol and restrictions that it imposes (i.e. patient uncomfortable to withstand a double scan on the day); Female participants of childbearing potential must confirm they are not pregnant (a strict requisite before 90Y-therapy anyway).

Where it's running

• The Christie NHS - Nuclear Medicine Department
  Manchester, United Kingdom Recruiting

Study contacts

• Study coordinator: Heather Williams
• Email: heather.williams34@nhs.net
• Phone: 01619187118

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.