Using Xian-Hua-Cha to reduce high cholesterol and obesity
The Efficacy of Xian-Hua-Cha for Improving Hyperlipidemia Among Obese Population: a Crossover Trial
This study is testing if a traditional Chinese herbal medicine called Xian-Hua-Cha can help people with obesity and high cholesterol feel better and improve their health.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 20 Years to 75 Years |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT05632068 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of Xian-Hua-Cha (XHC), a traditional Chinese herbal medicine, in alleviating hyperlipidemia among obese patients with a BMI of 27 or higher. It will involve 100 participants and utilize a crossover design to assess changes in body weight, body fat, and metabolic parameters such as blood sugar and cholesterol levels. The study will also monitor any adverse effects to ensure the safety of XHC. The findings could provide insights into natural treatments for obesity-related lipid disorders.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 20 to 75 with a BMI of 27 or higher and elevated cholesterol or triglyceride levels.
Not a fit: Patients with uncontrolled endocrine disorders, severe organ dysfunction, or those currently taking medications for obesity or hyperlipidemia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a natural and effective treatment option for patients struggling with hyperlipidemia and obesity.
How similar studies have performed: While there is growing interest in herbal treatments for obesity and metabolic disorders, most previous studies have been limited to animal models, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. BMI ≧ 27kg/m2 2. Total cholesterol \> 200 mg/dL or LDL \> 130 mg/dL or triglyceride \> 150 mg/dL 3. Age ≧ 20 years and \< 75 years 4. No recognition difficulties 5. Willing to sign inform consent and comply to protocol Exclusion Criteria: 1. Pregnant or breast-feeding women 2. Endocrine disorders (uncontrolled hypo/hyperthyroidism, adrenal gland disorder) 3. Diagnosis of neurologic or psychiatric diseases 4. Liver or renal dysfunction (AST/ALT higher than 3 times of upper normal limits; eGFR \< 60 mL/min/1.73 m2) 5. Acute stress condition (severe infection, receive major surgery in the recent 1 month) 6. Vision, or hearing impairment 7. With other clinical trial medication 8. With medication for obesity or hyperlipidemia in the recent 1 month 9. Heavy smoker, alcoholism or substance abuse 10. Severe organ dysfunction: malignancies, autoimmune diseases
Where this trial is running
Taoyuan
- Chang Gung Memorial Hospital, Linkou and Taoyuan branch — Taoyuan, Taiwan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.