Clinical trial Recruiting at 1 site Interventional Ages 18 to 35

Using wearable sensors to monitor mental fatigue and its effect on running performance

Official title: Monitoring the Effect of Mental Fatigue on Physical Performance Using Wearable Sensors and Physiological Parameters

Run by Vrije Universiteit Brussel · NCT07323810 · Data updated 2026-11-12

This project will test whether wearable sensors can detect mental fatigue in healthy trained runners (18–35) and predict how that fatigue affects a 5-km treadmill time trial.

More Mental Fatigue trials

Quick facts

Study typeInterventional
Ages18 Years to 35 Years
SexAll
Enrollment30 (estimated)
SponsorVrije Universiteit Brussel
Academic / other
Locations1 site (Brussels)
StatusRecruiting
StartedDecember 3, 2025
Main results expectedSeptember 2026
Study endsSeptember 2026
Registry record updatedAugust 18, 2026
Trial IDNCT07323810 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are healthy, non-smoking runners aged 18–35 who run regularly (≥15 km/week or ≥2 sessions/week for the past 6 months), take no medication, and have no neurological, cardiovascular, musculoskeletal, or psychiatric conditions.

Probably not a fit

People who are older, sedentary, on medication, smokers, have chronic health or psychiatric conditions, colour-vision deficiencies, or who are not experienced runners are unlikely to benefit from these specific results.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy, experienced runners complete two sessions in a randomized, counterbalanced crossover: a mental-fatigue induction using a Stroop cognitive task and a low-demand control (watching a documentary). During and after each session, heart rate variability, respiration rate, and pupil metrics are recorded continuously using wearable devices while participants perform a 5-km treadmill time trial. Machine learning models will use those physiological signals to predict mental-fatigue level and its impact on physical performance. The approach aims to produce a real-time, objective monitor of mental fatigue that can be used outside laboratory settings.

Why it matters

Potential benefit: If successful, wearable-based monitoring could let coaches, clinicians, and operators spot mental fatigue in real time and reduce performance drops or error risk by guiding rest or task adjustments.

How similar studies have gone: Previous small studies have shown wearable signals like HRV and pupil metrics can reflect fatigue, but combining these signals with machine learning to predict real-world performance is still relatively novel and not widely validated.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy (no neurological, cardiovascular or musculoskeletal disorders of any kind)
* Male or female
* No prior knowledge of the concept of MF
* No medication
* Non-smoker
* 18-35 years of age
* Experienced runners: (≥15km/week and/or ≥2u/week during the last 6 months)

Exclusion Criteria:

* Injuries in the past 6 months, affecting running performance
* Suffering from a chronic health condition (could be neurological, cardiovascular, internal or musculoskeletal)
* Participating in any concomitant care or research trials
* History of suffering from any mental/psychiatric disorders
* Use of medication
* Use of caffeine and heavy efforts 24 hours prior each trial
* Suffering from colour vision deficiencies
* Not eating a standardized meal, the morning of each trial and the evening before each trial

Where it's running

  • Brussels Labo voor Inspanning en Topsport
    Brussels, Belgium
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.