Using vancomycin powder with bone graft to prevent infections after spine surgery
Official title: Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Run by Taipei Veterans General Hospital, Taiwan · NCT03883022 · Data updated 2026-11-12
This study is testing if using vancomycin powder with bone grafts can help prevent infections after spine surgery for patients who haven't found relief from other treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Taipei Veterans General Hospital, Taiwan Government |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | September 3, 2018 |
| Main results expected | September 12, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | March 20, 2019 |
| Trial ID | NCT03883022 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients undergoing instrumented spine fusion surgery due to failed conservative treatment for degenerative lumbar disorders.
✕Probably not a fit
Patients who are allergic to vancomycin or unwilling to sign the informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of vancomycin powder combined with autogenous bone graft in preventing deep surgical site infections (DSSI) in patients undergoing spinal fusion surgeries. It aims to assess whether this combination can reduce the incidence of DSSI without negatively impacting bone fusion. The study includes patients who have not responded to conservative treatments and are undergoing instrumented spine fusion surgery. Participants will be monitored for infection rates and fusion outcomes post-surgery.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of infections following spinal surgeries, leading to better recovery outcomes for patients.
How similar studies have gone: While the use of antibiotics in surgical procedures is common, the specific combination of vancomycin with autogenous bone graft in spine surgery is a novel approach that has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have instrumented spine fusion surgery due to failed conservative treatment (bed rest, medication, rehabilitation programs) for 3 to 6 months * Patients who are willing to sign the surgical permit after the surgeon explains all surgical procedures along with the surgical risks * Patients who fully understand the surgical procedures as well as the surgical risks and are willing to sign the surgical permit and the inform consent * Patients who agree one more blood withdrawal after operation Exclusion Criteria: * Patients who agree to accept the spine surgery but do not agree to sign the inform consent * Patients who have allergic reaction to vancomycin
Where it's running
-
Taipei Veterans General Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Shih-Tien Wang, MD
- Email: stwang@vghtpe.gov.tw
- Phone: 886-2-28757557
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
PMCF look at METROSAN spinal systems and BONEGRAFT materials in adults after spine surgery
This PMCF study tests the safety and performance of METROSAN Titania spinal systems and Bonegraft materials in adults undergoing spinal fusion or stabilization in routine practice.
-
Evaluation of endoscopic procedures to avoid spinal fusion
This study tests if endoscopic procedures can help people with spinal stenosis and spondylolisthesis avoid the need for more invasive spinal fusion surgeries.
-
Modulating pulse-width during spinal surgery
This study is testing how different settings of electrical stimulation during spinal surgery can affect the safety and effectiveness of the procedure for patients.
-
Observational study on outcomes of lumbar spine surgery
This study is looking at how well different types of back surgery work for people with issues like herniated disks and spinal stenosis by tracking their pain, function, and satisfaction over time.
-
Data collection for patients undergoing lumbar spinal fusion with Implanet Jazz System
This study is collecting information from patients who have had back surgery using the Implanet Jazz System to see how well the device works over time.
-
Fusion versus decompression alone for single-level lumbar stenosis
This trial will test whether decompression surgery without added fusion works as well as decompression plus fusion for adults aged 45–75 with single-level lumbar spinal stenosis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.