Using ultrasound and microbubbles to improve blood flow in invasive breast cancer
Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer
This study is testing if using ultrasound with special microbubbles can boost blood flow to tumors in patients with invasive breast cancer to help make treatments more effective.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06158217 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of ultrasound-stimulated microbubbles on blood perfusion in patients with invasive breast cancer. Patients diagnosed with invasive breast cancer and scheduled for surgical resection will receive SonoVue® microbubbles, which are activated by ultrasound to enhance blood flow to the tumor. The study will measure changes in blood perfusion using contrast-enhanced ultrasound parameters such as peak intensity and area under the curve. The goal is to improve drug delivery by increasing blood perfusion, potentially overcoming drug resistance in chemotherapy.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a clinical diagnosis of invasive breast cancer and a tumor size of less than 4 cm.
Not a fit: Patients with severe cardiopulmonary insufficiency, allergies to SonoVue®, or those who have received neoadjuvant chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the effectiveness of chemotherapy by improving drug delivery to tumors.
How similar studies have performed: While the use of ultrasound and microbubbles is a novel approach, similar studies have shown promise in enhancing blood perfusion in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of Invasive Breast Cancer * patients scheduled to undergo surgical resection * maximum lesion diameter \< 4 cm * age over 18 years Exclusion Criteria: * patients with allergies to SonoVue® * patients with severe cardiopulmonary insufficiency, * patients who had already received neoadjuvant chemotherapy * pregnant women * individuals with mental illness * Patients who refused to participate in the study
Where this trial is running
Beijing
- Beijing Friendship Hospital, Capital Medical University — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Yunyun Dong, MS
- Email: 13811652027@163.com
- Phone: 01063138576
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.