Using two medications to prevent postpartum hemorrhage
Official title: A Randomized Controlled Trial of Double Simultaneous Uterotonic Agents (Misoprostol Plus Intravenous Oxytocin) Versus Single Agent Regimen (Intravenous Oxytocin Only) to Prevent Early Postpartum Hemorrhage
Run by Stony Brook University · NCT05245227 · Data updated 2026-11-12
This study tests if giving two medications together can better prevent heavy bleeding after childbirth in women delivering at Stony Brook University Hospital.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 1358 (estimated) |
| Sponsor | Stony Brook University Academic / other |
| Locations | 1 site (Stony Brook, New York) |
| Status | Recruiting |
| Started | January 27, 2025 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | May 4, 2025 |
| Trial ID | NCT05245227 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18 and older who are admitted for delivery at Stony Brook University Hospital.
✕Probably not a fit
Patients who may not benefit include those under 18, those with coagulation disorders, planned cesarean hysterectomy, placental accreta spectrum disorders, or allergies to prostaglandins.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of administering two uterotonic agents, misoprostol and oxytocin, simultaneously compared to the standard single-agent regimen of oxytocin alone in preventing early postpartum hemorrhage. The research will involve women aged 18 and older who are admitted for delivery at Stony Brook University Hospital. The study will also assess any potential side effects associated with the dual medication approach. By comparing the outcomes of both regimens, the study seeks to provide insights into the best practices for managing postpartum hemorrhage.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postpartum hemorrhage, improving maternal health outcomes.
How similar studies have gone: Previous studies have indicated that using two medications may reduce the odds of postpartum hemorrhage, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- All women 18 years and older admitted to delivery at Stony Brook University hospital who agree to participate in the study Exclusion Criteria: * Women under 18 years old * Women with known coagulation disorders * Women with planned cesarean hysterectomy * Women with known placental accreta spectrum disorders * Women with known allergy to prostaglandins
Where it's running
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Stony Brook University
Stony Brook, New York, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.