Using the respiratory quotient (RQ) to guide nutrition for ICU patients
Official title: Will the Use of Respiratory Quotient "RQ" to Optimize Nutrition Therapy With Indirect Calorimetry Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
Run by Poznan University of Medical Sciences · NCT07457554 · Data updated 2026-11-12
This project will test if using the respiratory quotient (RQ) from indirect calorimetry to guide calorie delivery improves outcomes for mechanically ventilated ICU patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 236 (estimated) |
| Sponsor | Poznan University of Medical Sciences Academic / other |
| Locations | 1 site (Poznan, Wielkopolska) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | September 30, 2027 |
| Study ends | October 31, 2027 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07457554 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Mechanically ventilated adult ICU patients treated at the enrolling center, covered by universal health insurance, who are not on ECMO and have FiO2 ≤ 60% are ideal candidates.
✕Probably not a fit
Patients on ECMO, with FiO2 > 60%, breathing without ventilator support, pregnant patients, or those not expected to survive 48 hours are not eligible and unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares RQ-guided nutrition to standard guideline-based nutritional care in mechanically ventilated ICU patients. RQ and resting energy expenditure will be obtained with indirect calorimetry and used to adjust calorie provision in the intervention arm, while the control arm receives nutrition per current guidelines. Patients on ECMO, with very high oxygen needs (FiO2 >60%), or not expected to survive 48 hours are excluded. The study is conducted at the University Clinical Hospital in Poznań under the Poznan University of Medical Sciences.
Why it matters
Potential benefit: If successful, RQ-guided feeding could reduce overfeeding and underfeeding and improve recovery and survival by tailoring nutrition to each patient's metabolic state.
How similar studies have gone: Indirect calorimetry is established as the gold standard for measuring energy needs, but using RQ specifically to guide nutrition is relatively novel and prior outcome data are limited and mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient treated in the ICU * mechanically ventilated * covered by universal health insurance Exclusion Criteria: * ECMO therapy * mechanical ventilation with an oxygen concentration in the breathing mixture FiO2 \> 60% * breathing independently without the aid of a ventilator * critically ill patients who are not expected to survive the next 48 hours * pregnant women
Where it's running
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University Clinical Hospital in Poznań, ul. Przybyszewskiego 49, Clinical Department of Anesthesiology, Intensive Care, and Pain Management
Poznan, Wielkopolska, Poland Recruiting
Study contacts
- Principal investigator: Amadeusz Juliusz Woźniak, MD — University Clinical Hospital in Poznań, ul. Przybyszewskiego 49, Clinical Department of Anesthesiology, Intensive Care, and Pain Management
- Study coordinator: Amadeusz Juliusz Woźniak, MD
- Email: amadeusz.wozniak@ump.edu.pl
- Phone: +48 603 927 222
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.