Using the respiratory quotient (RQ) to guide nutrition for ICU patients
Will the Use of Respiratory Quotient "RQ" to Optimize Nutrition Therapy With Indirect Calorimetry Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
This project will test if using the respiratory quotient (RQ) from indirect calorimetry to guide calorie delivery improves outcomes for mechanically ventilated ICU patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Poznan University of Medical Sciences Academic / other |
| Locations | 1 site (Poznan, Wielkopolska) |
| Trial ID | NCT07457554 on ClinicalTrials.gov |
What this trial studies
This interventional study compares RQ-guided nutrition to standard guideline-based nutritional care in mechanically ventilated ICU patients. RQ and resting energy expenditure will be obtained with indirect calorimetry and used to adjust calorie provision in the intervention arm, while the control arm receives nutrition per current guidelines. Patients on ECMO, with very high oxygen needs (FiO2 >60%), or not expected to survive 48 hours are excluded. The study is conducted at the University Clinical Hospital in Poznań under the Poznan University of Medical Sciences.
Who should consider this trial
Good fit: Mechanically ventilated adult ICU patients treated at the enrolling center, covered by universal health insurance, who are not on ECMO and have FiO2 ≤ 60% are ideal candidates.
Not a fit: Patients on ECMO, with FiO2 > 60%, breathing without ventilator support, pregnant patients, or those not expected to survive 48 hours are not eligible and unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, RQ-guided feeding could reduce overfeeding and underfeeding and improve recovery and survival by tailoring nutrition to each patient's metabolic state.
How similar studies have performed: Indirect calorimetry is established as the gold standard for measuring energy needs, but using RQ specifically to guide nutrition is relatively novel and prior outcome data are limited and mixed.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient treated in the ICU * mechanically ventilated * covered by universal health insurance Exclusion Criteria: * ECMO therapy * mechanical ventilation with an oxygen concentration in the breathing mixture FiO2 \> 60% * breathing independently without the aid of a ventilator * critically ill patients who are not expected to survive the next 48 hours * pregnant women
Where this trial is running
Poznan, Wielkopolska
- University Clinical Hospital in Poznań, ul. Przybyszewskiego 49, Clinical Department of Anesthesiology, Intensive Care, and Pain Management — Poznan, Wielkopolska, Poland (Recruiting)
Study contacts
- Principal investigator: Amadeusz Juliusz Woźniak, MD — University Clinical Hospital in Poznań, ul. Przybyszewskiego 49, Clinical Department of Anesthesiology, Intensive Care, and Pain Management
- Study coordinator: Amadeusz Juliusz Woźniak, MD
- Email: amadeusz.wozniak@ump.edu.pl
- Phone: +48 603 927 222
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.