Using thalidomide to prevent or treat skin growths caused by camrelizumab in lung and esophageal cancer patients

A Prospective, Randomized Clinical Study of the Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP) With Thalidomide

This study is testing if thalidomide can help prevent or treat skin growths caused by a cancer treatment in patients with advanced lung and esophageal cancer.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 132 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Henan Cancer Hospital (Government)
• Drugs / interventions: Camrelizumab, chemotherapy
• Locations: 2 sites (Zhengzhou, Henan and 1 other locations)
• Trial ID: NCT06231680 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the safety and dosage of thalidomide for preventing and treating reactive cutaneous capillary endothelial proliferation (RCCEP) in patients with advanced non-small cell lung cancer and esophageal squamous cell carcinoma. Participants scheduled to receive camrelizumab combined with platinum-based chemotherapy will be enrolled. The study will assess the effectiveness of different doses of thalidomide in both preventing RCCEP and treating patients who develop moderate to severe RCCEP. The trial is designed to provide evidence for thalidomide's role in managing this specific side effect of cancer treatment.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with advanced non-small cell lung cancer or esophageal squamous cell carcinoma who are starting treatment with camrelizumab and platinum-based chemotherapy.

Not a fit: Patients who have previously received therapy with anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibodies may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a new method to prevent and treat skin-related side effects in cancer patients undergoing camrelizumab therapy.

How similar studies have performed: While thalidomide has been used in various contexts, this specific application for RCCEP in conjunction with camrelizumab is novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

* Prevention cohort 1:

  1. Histopathology or cytology confirmed advanced non-small cell lung cancer or esophageal squamous cell carcinoma; no previous systemic therapy (patients who had progressed ≥6 months after \[neo\] adjuvant therapy were eligible).
  2. A treatment regimen of Camrelizumab combined with platinum-containing chemotherapy is planned.
  3. ECOG: 0-1;
  4. Age ≥18 years old;
  5. Have a life expectancy of at least 12 weeks;
  6. No prior therapy with anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody (including any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways).
  7. Can swallow pills normally;
  8. Adequate organ and bone marrow function：Standard of blood routine examination (without transfusion within 14 days) : Hemoglobin (HB) ≥80 g/L; Neutrophil absolute value (ANC) ≥1.5×10\^9/L; Platelet (PLT) ≥90×10\^9/L;Biochemical examination should meet the following criteria: Total bilirubin (TBIL) ≤1.5 times the upper limit of normal value (ULN); Alanine aminotransferase (ALT), aspartate aminotransferase (AST) ≤3×ULN; Serum creatinine (Cr) ≤1.5 ULN;
  9. Female Subjects of childbearing potential must have a negative serum pregnancy test within 72 hours before the first dose and must be willing to use very efficient barrier methods of contraception for the course of the study through 2 months after the last dose of study treatment. Male Subjects with a female partner(s) of child-bearing potential must be willing to use very efficient barrier methods of contraception for the course of the study through 2 months after the last dose of study treatment;
  10. Subjects has voluntarily agreed to participate by giving written informed consent/assent for the trial.
* Treatment cohort 2:

  1. Histopathology or cytology confirmed advanced lung cancer or esophageal carcinoma;
  2. Subjects had≥G2 grade RCCEP for the first time after treatment with a Camrelizumab based regimen;
  3. ECOG: 0-2;
  4. Age ≥18 years old;
  5. Have a life expectancy of at least 12 weeks;
  6. Can swallow pills normally;
  7. No ongoing grade 3 or higher adverse events except for RCCEP (according to CTCAE version 5.0).
  8. Female Subjects of childbearing potential must have a negative serum pregnancy test within 72 hours before the first dose and must be willing to use very efficient barrier methods of contraception for the course of the study through 2 months after the last dose of study treatment. Male Subjects with a female partner(s) of child-bearing potential must be willing to use very efficient barrier methods of contraception for the course of the study through 2 months after the last dose of study treatment;
  9. Subjects have voluntarily agreed to participate by giving written informed consent/assent for the trial.

Exclusion Criteria:

* Prevention cohort 1:

  1. Known allergy to the investigational drug or excipient, history of severe hypersensitivity reactions to other monoclonal antibodies.
  2. Subjects with a condition requiring systemic treatment with other immunosuppressive medications within 14 days of first administration of study treatment.
  3. Subjects had administration of a live, attenuated vaccine within 4 weeks of the first dose of study treatment or anticipation that such a live attenuated vaccine will be required during the study.
  4. Advanced patients who have symptoms, have spread to the internal organs, and are at risk of developing life-threatening complications in the short term;
  5. Subjects with a history of interstitial lung disease, or other disease may interfere with the detection or treatment of suspected drug-related lung toxicity.
  6. Subjects with active, known or suspected autoimmune disease. Subjects in conditions not expected to recur in the absence of an external trigger, or not requiring systemic treatment are permitted to enroll.
  7. HIV infection; Combined hepatitis B and hepatitis C co-infection
  8. Subjects with active CNS metastases are excluded.
  9. Subjects with clinically significant cardiovascular and cerebrovascular diseases.
  10. Coagulation abnormalities, with bleeding tendency or are receiving thrombolytic or anticoagulant therapy;
  11. Disposition evidence of hemoptysis in 2 months (bright red blood, 1/2 teaspoon).
  12. History of hemorrhage within 3 months prior to the start of study treatment or clear tendency of hemorrhage
  13. Thrombosis or thromboembolic event within 6 months prior to the start of study treatment;
  14. Active infection (CTCAE\> Grade 2)
  15. Subjects had or plan to have allogeneic bone marrow transplantation or solid organ transplant.
  16. Subjects are currently participating and receiving study therapy or had participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks or 5 half-value period life of the agent, before the first dose of trial treatment.
  17. Subjects have known psychiatric or substance abuse disorder
  18. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating Investigator.
* Treatment cohort 2:

  1. Known allergy to the investigational drug or excipient
  2. Advanced patients who have symptoms, have spread to the internal organs, and are at risk of developing life-threatening complications in the short term;
  3. Subjects with a history of interstitial lung disease, or other disease may interfere with the detection or treatment of suspected drug-related lung toxicity.
  4. HIV infection; Combined hepatitis B and hepatitis C co-infection
  5. Active infection (CTCAE\> Grade 2)
  6. Subjects have known psychiatric or substance abuse disorder
  7. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating Investigator

Where this trial is running

Zhengzhou, Henan and 1 other locations

• Ying Liu — Zhengzhou, Henan, China (Recruiting)
• The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China (Not_yet_recruiting)

Study contacts

• Principal investigator: Ying Liu, MD — Henan Cancer Hospital
• Study coordinator: Ying Liu, MD

Conditions Lung Cancer, Nonsmall Cell; Esophageal Carcinoma