Using terlipressin to manage blood pressure during kidney transplantation
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation, a Double-blind Randomized Controlled Trial
This study tests if using terlipressin can help keep blood pressure stable during kidney transplants better than the usual treatment with dobutamine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06855758 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of terlipressin in maintaining blood pressure during kidney transplantation compared to the conventional drug dobutamine. Patients undergoing the procedure are randomly assigned to receive either terlipressin-complexed dobutamine or standard dobutamine treatment. The study aims to evaluate intraoperative blood pressure stability, postoperative graft function, and the incidence of delayed graft function and related complications. By comparing these outcomes, the trial seeks to determine if terlipressin offers superior benefits over existing treatments.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with end-stage renal disease who are scheduled for kidney transplantation.
Not a fit: Patients undergoing simultaneous multiple organ transplantation or those with severe preoperative hypertension may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved blood pressure management and better outcomes for kidney transplant patients.
How similar studies have performed: While the use of terlipressin in this context is being explored, similar studies have not been widely reported, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with end-stage renal disease aged 18 years or above Exclusion Criteria: * simultaneous multiple organ transplantation * known allergy to study medication * known pregnancy status * cancellation of surgery due to grafts or personal reasons * persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications * any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study
Where this trial is running
Beijing
- Beijing Friendship Hospital — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Fushan Xue — Department of Anesthesiology, Beijing Friendship Hospital
- Study coordinator: Wenhe Yang
- Email: 13810673664@163.com
- Phone: 86 13810673664
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.