Using surgical glove-compression therapy to prevent nerve damage from paclitaxel

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of surgical glove-compression therapy (SGCT) in preventing sensory peripheral neuropathy caused by paclitaxel chemotherapy. Participants will be randomly assigned to either receive SGCT or non-compressive plastic gloves during their treatment. The study will assess the incidence of grade 2 or higher sensory peripheral neuropathy using established criteria and will also evaluate secondary outcomes related to motor neuropathy and overall neurotoxicity. Data will be collected at multiple time points throughout the chemotherapy regimen, and a total of 36 patients will be enrolled for this trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed Informed Consent Form
* Age 18 years or older at the time of signing Informed Consent Form
* Patients with any pathological diagnosis of solid tumor, such as breast cancer or lung cancer
* Patients scheduled to be receiving intravenous paclitaxel or paclitaxel-based regimen every 3 weeks

Exclusion Criteria:

* Patients whose received chemotherapeutic agents that could cause neuropathy, e.g. taxane-based or platinum-based chemotherapy and anti-microtubule
* History of neuropathy
* History of carpal tunnel syndrome
* History of allergic reactions to latex or gloves
* Patients receiving treatments that may treat neuropathy, e.g. amitriptyline, gabapentin, Acetyl L-Carnitine and Ganglioside-monosialic acid, acupuncture, cryotherapy or exercise therapy
* History of Raynaud phenomenon
* History of wounds or large scars on hands
* Pregnancy or breastfeeding
* History of poorly controlled diabetes; HbA1c\>6.5

Where it's running

• Rajavithi Hospital, Medical Oncology Unit
  Bangkok, Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Saowani Thantaviraya, M.D. — Department of Medical Services Ministry of Public Health of Thailand
• Study coordinator: Saowani Thantaviraya, M.D.
• Email: saowani.mook@gmail.com
• Phone: +66805564241

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.