Cold salt-water foot baths to prevent paclitaxel-related nerve damage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, controlled trial that assigns Turkish-speaking women with breast cancer receiving paclitaxel to cold salt-water foot baths, unsalted cold-water foot baths, or standard care. Interventions are delivered during chemotherapy and participants are monitored over time using neuropathy screening tools such as the CIPNAT scale, monofilament testing, and vibration testing to track onset, severity, and functional impact. The primary aims are to reduce the incidence and severity of chemotherapy-induced peripheral neuropathy and its effects on daily activities. Key exclusion criteria include preexisting neuropathy, diabetes, foot ulcers, peripheral vascular or nervous system disease, and bone or soft tissue metastases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 and over.
* Conscious
* Speaking and understanding Turkish
* The diagnosis was breast cancer
* Those who will receive paclitaxel chemotherapy
* These are patients who answered 'no' to the 'A' section of the CIPNAT scale

Exclusion Criteria:

* Responding to the vibration test (if the practitioner does not feel the vibration when the patient says they feel the vibration, it means that neuropathy is present)
* Feeling pressure in one or none of the three areas on the plantar surface of the foot according to the monofilament test
* Previous chemotherapy-associated peripheral neuropathy
* Diagnosed with diabetes
* Open wounds or skin ulcers on the foot
* With peripheral and central nervous system disease
* Peripheral vascular disease,
* Patients with bone or soft tissue metastases

Where it's running

• Haydarpaşa Numune Training and Research Hospital
  Istanbul, Uskudar, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tuba Eryigit, PhD student
• Email: tubaeryigit@topkapi.edu.tr
• Phone: +905059683332

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cryotherapy during weekly paclitaxel to reduce chemotherapy-induced numbness and tingling

  This study tests whether applying cryotherapy to hands and feet during weekly paclitaxel helps prevent CIPN in women with breast cancer.

  Recruiting at 3 sites Azienda Sanitaria dell'Alto Adige · Bolzano, Bolzano and 3 other locations · NCT07780955

• Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy

  This study tests whether adding a structured exercise program to electroacupuncture helps cancer survivors with CIPN more than electroacupuncture alone.

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• Virtual exercise program to help with chemotherapy-induced nerve symptoms

  This trial tests whether a remote, personalized exercise program (EX-CIPN) can reduce CIPN symptoms and related disability in cancer survivors who have persistent neuropathy after chemotherapy, compared with usual care.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT07481149

• Hyperbaric oxygen therapy for nab-paclitaxel-induced neuropathy in breast cancer

  This study tests whether hyperbaric oxygen therapy can help relieve neuropathy from nab-paclitaxel in adult women with breast cancer who have finished chemotherapy.

  Recruiting at 2 sites Phase 2/3 Guangdong Provincial People's Hospital · Guangzhou, Guangdong and 1 other locations · NCT07410169

• Acupuncture and compression to prevent chemotherapy-induced nerve damage in breast cancer

  This trial will test whether wearing compression garments and/or receiving acupuncture during taxane chemotherapy can prevent chemotherapy-induced peripheral neuropathy in adults with early-stage breast cancer.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07377279

• PEA and Scutellaria combined with exercise for chemotherapy-related nerve pain

  This trial will see if taking PEA and Scutellaria together with therapeutic exercise helps adults who have nerve pain after chemotherapy.

  Recruiting University of Palermo · Palermo, Italia · NCT07352514

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.