Using stem cells to treat venous leg ulcers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of local transplantation of human umbilical cord mesenchymal stem cells combined with silver ion dressing compared to silver ion dressing alone in treating venous leg ulcers. The study aims to improve the healing rate and quality of life for patients suffering from chronic wounds that have not healed after conventional treatments. Participants will be monitored for their wound healing progress over the course of the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age from 18 to 70, no gender limitation;
2. It met the diagnostic criteria of venous ulcer of lower limbs in Clinical Vascular Surgery (5th edition), and the following conditions were met: the ulcer lasted for more than 1 month; The wound area was between 10cm2 and 40cm2. Wound depth: All wounds were deep tissue ulcers below the epidermis.
3. Participate in the clinical study voluntarily, observe the study procedure, and observe the curative effect cooperatively.

Exclusion Criteria:

1. Pregnant or lactation women; Women who have planned to have children recently (within 6 months);
2. Patients with peripheral artery disease with ankle-brachial index (ABI) \< 0.8;
3. Patients with active clinical systemic infection;
4. Serious skin wound infection is not under control;
5. low immune function and systemic failure; Severe heart, liver, lung, kidney and other important organ lesions (ALT, AST, Cr \& GT; Normal 1.5 times, congestive heart failure ejection fraction \&lt; Normal 30%) and severely impaired hematopoietic function;
6. Abnormal coagulation function or current anticoagulant treatment;
7. Systemic autoimmune diseases in the active stage;
8. With systemic organ or hematological malignancy;
9. PERSONS infected with HIV or addicted to drugs, tobacco and alcohol;
10. Have a clear history of mental illness;
11. Participation in clinical studies of any drug within 1 month prior to treatment (or the 5 half-life of the investigational drug, whichever is longer).

Where it's running

• Southwest Hospital, Army Medical University (Third Military Medical University)
  Chongqing, Chongqing Municipality, China Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PAW-hydrogel to help chronic wounds like diabetic foot and leg ulcers heal faster

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• GORE VIABAHN FORTEGRA Venous Stent Post-Approval Study

  This study tests the GORE VIABAHN FORTEGRA Venous Stent in real-world patients with venous diseases to see how it performs after it is approved.

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• Human placental membrane products plus standard care for nonhealing diabetic foot and venous leg ulcers

  This trial will try human placental membrane products together with standard wound care to help adults whose diabetic foot ulcers or venous leg ulcers have not healed.

  Recruiting BioLab Holdings · Philidelphia, Pennsylvania · NCT07364630

• See if Hyalomatrix helps heal venous leg ulcers faster when added to standard care

  This trial tests whether adding Hyalomatrix to standard wound care helps people with venous leg ulcers heal more effectively.

  Recruiting at 9 sites NuScience Medical Biologics, LLC · Alexandria, Louisiana and 11 other locations · NCT07335861

• Suprasorb X+PHMB Pro versus Suprasorb X+PHMB for infected venous leg ulcers

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  Recruiting at 7 sites Lohmann & Rauscher · Bialystok and 8 other locations · NCT07211243

• Using human placental membrane wraps with regular wound care to help heal stubborn diabetic foot and venous leg ulcers

  This trial tests whether adding one of four human placental membrane wraps to standard wound care helps people with nonhealing diabetic foot or venous leg ulcers heal faster and more completely than standard care alone.

  Recruiting Phase 4 BioLab Holdings · Philidelphia, Pennsylvania · NCT07089602

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.